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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
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Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review

机译：外源性雄激素对血小板活性及其血栓性激素潜力的影响及其血栓形成潜力：文献综述

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Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential.
机译：合成代谢雄激素类固醇（AAS），简称为“Androgens”，代表最普遍的药物，用于增强体育环境中的性能和外观。高剂量和/或长期AAS给药经常在心血管系统中具有显着的改变，其中一些具有严重的终点。一个血栓前状态的诱导可能是最危及生命的后果，由AAS-滥用的运动员众多病例报告建议，以及相当数量的评估外源性雄激素止血的影响人类和动物的研究。尽管有五十年的研究，关于外源性雄激素的血栓形成潜力的数据仍然稀缺。主要原因是开展人类前瞻性研究的可能性有限。然而，在运动员或患者中进行的人类观察研究，体外人类研究和动物实验已经指出，起步性剂量中的雄激素诱导增强的血小板活性和血栓形成，导致血小板聚集增加。如果这种趋势与先前存在的凝血和/或纤维蛋白溶解功能障碍重叠，则可能导致血栓形成素质，这可以解释滥用AAS滥用人口中的巨大血栓栓塞事件。雄激素过量对血小板活性和流体凝血的影响仍然是辩论的主题，促使补充研究，以澄清对止血的影响，并为其所要求保护的血栓形成潜力提供新的令人信服的证据。

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