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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Resveratrol-Based Multivitamin Supplement Increases Sperm Concentration and Motility in Idiopathic Male Infertility: A Pilot Clinical Study
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Resveratrol-Based Multivitamin Supplement Increases Sperm Concentration and Motility in Idiopathic Male Infertility: A Pilot Clinical Study

机译：基于白藜芦醇的多种维生素补充剂增加了特发性男性不孕症中的精子浓度和动力：试验临床研究

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Background. It is known that a multitude of factors may lead to male factor infertility, but still, in the majority of cases, the cause remains largely idiopathic, reflecting poor understanding of the basic process of spermatogenesis and the mechanisms involved. Resveratrol is a polyphenol compound that displays several cellular aspects mainly associated with SIRT1-pathway activation and promotion of mitochondrial enhancer activities. In several animal models, resveratrol has shown positive effects on mitochondria and membrane potential. This could explain effects on sperm concentration and motility. The aim of this study is to evaluate the effects on the semen parameters of GENANTE®, a multivitamin supplement containing 150 mg of resveratrol/day, in patients with idiopathic infertility. Methods. This was a prospective single center clinical study. Twenty patients took a multivitamin supplement based on 150 mg of resveratrol (GENANTE®), in the form of an oral tablet every 12 h, and were followed up at 1, 3, and 6 months after treatment. Pre- and post-treatment evaluation included history, clinical examination, semen analysis, hormonal determinations, and scrotal and prostatic ultrasound. Results. Our preliminary pilot study demonstrated that the multivitamin supplement based on resveratrol improves sperm motility (48.3% ± 13.8 vs. 59.0% ± 12.8, p = 0.0001) and concentration (22.6 × 106/mL ± 9.5 vs. 25.7 × 106/mL ± 8.1, p = 0.0001) after 3 and 6 months of treatment in men with idiopathic infertility. Conclusion. Our data suggest that targeting the metabolic and energetic pathways involved in spermatogenesis and mitochondrial activity could lead to potential effects and counteract subfertility/infertility in men through a mitochondria dynamics mechanism. Trial registration number: ClinicalTrials.gov registration identifier: {"type":"clinical-trial","attrs":{"text":"NCT03864198","term_id":"NCT03864198"}}NCT03864198, registered on 1 January 2019.
机译：背景。众所周知，多种因素可能导致男性因子不孕，但在大多数情况下，原因仍然很大程度上是特发性的，反映了对精子发生的基本过程和所涉及的机制的理解。白藜芦醇是一种多酚化合物，其显示出主要与SIRT1-途径激活和线粒体增强剂活性促进相关的几种细胞方面。在几种动物模型中，白藜芦醇对线粒体和膜电位显示了积极影响。这可以解释对精子浓度和运动的影响。本研究的目的是评估特发性不孕症的患者患者对含有150mg白藜芦醇/天的多种维生素补充剂的Genante®的精液参数的影响。方法。这是一项潜在的单中心临床研究。二十名患者以每12小时的口服片剂的150mg白藜芦醇（Genante®）进行多种维生素补充剂，并在治疗后的1,3和6个月内随访。治疗后和后后评估包括历史，临床检查，精液分析，激素测定和阴囊和前列腺超声。结果。我们的初步试验研究表明，基于白藜芦醇的多种维生素补充剂改善了精子运动（48.3％±13.8，59.0％±12.8，p = 0.0001）和浓度（22.6×106 / ml±9.5与25.7×106 / ml±8.1 ，p = 0.0001）在特发性不孕症的男性治疗3和6个月后。结论。我们的数据表明，针对涉及精子发生和线粒体活性的代谢和能量途径可能导致通过线粒体动力学机制导致男性的潜在影响和抗衡患者/不孕症。试验登记号码：ClinicalTrials.gov注册标识符：{“类型”：“临床 - 试验”，“attrs”：{“text”：“nct03864198”，“term_id”：“nct03864198”} NCT03864198，2019年1月1日注册。

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