首页> 美国卫生研究院文献>Journal of Medical Case Reports >Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report
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Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report

机译:用丝裂剂活化蛋白激酶和免疫检查点抑制剂治疗转移性黑素瘤的患者中的非典型抗肾小球膜肾小球肾炎:案例报告

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摘要

a Chronic active interstitial nephritis with focal cellular crescents and linear IgG immunoglobulin deposition. Widespread acute tubular injury with luminal dilatation and flattened epithelium. A glomerulus demonstrates segmental sclerosis and capsular adhesion, possibly and previous crescent (arrow) (hematoxylin and eosin [H&E], original magnification 40×). b Glomerulus with cellular crescent (periodic acid–Schiff [PAS], original magnification 200×). c Immunofluorescence microscopy demonstrates linear staining for Immunoglobulin G along peripheral capillary loops of all glomeruli (original magnification 200×), also for positive linear IgG3+, IgA 2+, Kappa 2+, Lambda 2 anti-glomerular basement membrane glomerulonephritis (not shown)
机译:慢性活性间质性肾炎,具有焦细胞下划线和线性IgG免疫球蛋白沉积。具有腔扩张和扁平上皮的广泛急性管状损伤。肾小球证明了节段性硬化和荚膜粘附,可能和以前的新月(箭头)(苏木精和eosin [H&E],原始放大倍数40×)。 B肾小球与细胞新月(周期性酸 - 席夫[PAS],原始倍率200×)。 C免疫荧光显微镜证明了沿所有肾小球(原始倍率200×)的外周毛细管循环的直线染色的线性染色,也用于正线性IgG3 +,IgA 2+,κ2+,λ2抗肾小球基底肾小球肾炎(未示出)

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