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Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

机译：虾青素和血小阴对胶质母细胞瘤的抗肿瘤作用

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摘要

Several antitumour drugs have been isolated from natural products and many clinical trials are underway to evaluate their potential. There have been numerous reports about the antitumour effects of astaxanthin against several tumours but no studies into its effects against glioblastoma. Astaxanthin is a red pigment found in crustaceans and fish and is also synthesized in Haematococcus pluvialis; adonixanthin is an intermediate product of astaxanthin. It is known that both astaxanthin and adonixanthin possess radical scavenging activity and can confer a protective effect on several damages. In this study, we clarified the antitumour effects of astaxanthin and adonixanthin using glioblastoma models. Specifically, astaxanthin and adonixanthin showed an ability to suppress cell proliferation and migration in three types of glioblastoma cells. Furthermore, these compounds were confirmed to transfer to the brain in a murine model. In the murine orthotopic glioblastoma model, glioblastoma progression was suppressed by the oral administration of astaxanthin and adonixanthin at 10 and 30 mg/kg, respectively, for 10 days. These results suggest that both astaxanthin and adonixanthin have potential as treatments for glioblastoma.
机译：几种抗真菌药物已经从天然产品中分离出来，并且正在进行许多临床试验来评估它们的潜力。有许多关于虾青素对几种肿瘤的抗胃溃疡影响的报告，但没有研究其对胶质母细胞瘤的影响。虾青素是在甲壳类动物和鱼类中发现的红色颜料，也在Haematococcus Pluvialis中合成; Adonixanthin是虾青素的中间产物。众所周知，斯塔什林和血小蛋白均具有自由基清除活性，并且可以对几种损害赋予保护作用。在这项研究中，我们用胶质母细胞瘤模型阐明了虾青素和血小腺素的抗肿瘤作用。具体而言，虾青素和adonixanthin显示出抑制细胞增殖和三种类型的胶质母细胞瘤细胞的迁移的能力。此外，证实这些化合物在鼠模型中转移到脑中。在鼠原位胶质母细胞瘤模型中，通过分别在10和30mg / kg的虾青素和血小腺素中抑制胶质母细胞瘤进展10天。这些结果表明，斯坦桑蛋白和血小蛋白均具有潜力作为胶质母细胞瘤的治疗方法。

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