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首页> 美国卫生研究院文献>Medicina >Bilateral Ultrathin Descemet’s Stripping Automated Endothelial Keratoplasty vs. Bilateral Penetrating Keratoplasty in Fuchs’ Dystrophy: Corneal Higher-Order Aberrations Contrast Sensitivity and Quality of Life
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Bilateral Ultrathin Descemet’s Stripping Automated Endothelial Keratoplasty vs. Bilateral Penetrating Keratoplasty in Fuchs’ Dystrophy: Corneal Higher-Order Aberrations Contrast Sensitivity and Quality of Life

机译：双侧超薄Descemet的剥离自动内皮角膜变形术与双边穿透角膜术在Fuchs营养不良症中：角膜高阶畸变对比敏感性和生活质量

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Background and Objectives: The objective of this paper is to compare the visual outcomes and quality of life (QoL) after bilateral ultrathin Descemet’s stripping automated endothelial keratoplasty (UT-DSAEK) with bilateral penetrating keratoplasty (PK) for Fuchs’ endothelial dystrophy (FED). Materials and Methods: Retrospective comparative cohort study, including 11 patients with FED who underwent bilateral PK and 13 patients with FED who underwent bilateral UT-DSAEK. All patients were already pseudophakic or had undergone a combined cataract procedure. The main outcomes were corrected distance visual acuity (CDVA) corneal higher-order aberrations (HOAs), contrast sensitivity (CS) and quality of life (QoL). Results: The mean follow-up after the second eye surgery was 32.5 ± 10.2 months in PK and 19.6 ± 8.6 months in UT-DSAEK patients. The CDVA in the UT-DSAEK group was significantly better than in the PK one (0.18 ± 0.07 vs. 0.35 ± 0.16 logMAR, p < 0.0001). The mean anterior corneal total HOAs of the central 5 mm were significantly lower in UT-DSAEK eyes than in PK eyes (0.438 ± 0.078 µ and 1.282 ± 0.330 µ respectively, p < 0.0001), whilst the mean posterior total HOAs did not differ between groups (0.196 ± 0.056 µ and 0.231 ± 0.089 µ, respectively, p = 0.253). The CS was lower at 0.75 and 1.5 cycles/degree in P the K group when compared to the DSAEK one (p = 0.008 and 0.005, respectively). The QoL scores by the NEI RQL-42 test exhibited better values in DSAEK patients in 9 out of 13 scales. Conclusion: Our study confirms that UT-DSAEK provides a better visual function in terms of CDVA and CS, together with lower HOAs, when compared to PK. Hence, the vision-related QoL, binocularly evaluated by the NEI RQL-42 items, indicates a higher satisfaction in UT-DSAEK eyes.
机译：背景和目标：本文的目的是比较双侧超薄Descemet剥离自动内皮角膜术（UT-dsaek）与双边穿透角膜术（PK）进行福富型内皮营养不良术（FED）后的视觉结果和生活质量（QOL） 。材料与方法：回顾性比较队列研究，其中11例喂养双侧PK和13名喂养双边富德氏患者的患者。所有患者均为假期或经过组合的白内障程序。主要结果是矫正距离视力（CDVA）角膜高阶像差（HOAS），对比度敏感度（CS）和生活质量（QOL）。结果：在UT-DSAEK患者中，第二眼手术后的平均随访32.5±10.2个月，19.6±8.6个月。 UT-DSAEK组中的CDVA显着优于PK One（0.18±0.07 Vs. 0.35±0.16 Logmar，P <0.0001）。 UM-Dsaek眼睛的平均前角膜总HOA显着低于PK眼睛（0.438±0.078μ和1.282±0.330μ，P <0.0001），而平均后的HOA没有区别分别组（0.196±0.056μ和0.231±0.089μm，p = 0.253）。与DSAEK一体相比，Cs在K组中的0.75和1.5次循环/度下降（分别为0.008和0.005）。 NEI RQL-42测试的QOL分数在13级中的9例中发表了DSAEK患者的更好的价值。结论：我们的研究证实，与PK相比，UT-DSAEK在CDVA和CS方面提供了更好的视觉功能，以及下部的HOA。因此，与NEI RQL-42项的视觉相关QOL，双目评估，表明UT-DSAEK眼睛的满意度更高。

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