• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Marine Drugs >Extraction Improvement of the Bioactive Blue-Green Pigment Marennine from Diatom
【2h】

Extraction Improvement of the Bioactive Blue-Green Pigment Marennine from Diatom

机译：从硅藻中提取生物活性蓝绿色颜料玛永宁的改进

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The compound “marennine” is a blue–green pigment produced by the benthic microalgae Haslea ostrearia, with pathogenicity reduction activities against some bacteria and promising potential as a natural pigment in seafood industries. After decades of research, the chemical family of this compound still remains unclear, mainly because structural studies were impaired by the presence of co-extracted compounds in marennine isolates. To improve the purity of marennine extract, we developed a novel extraction method using a graphitic stationary phase, which provides various advantages over the previous procedure using tandem ultrafiltration. Our method is faster, more versatile, provides a better crude yield (66%, compared to 57% for ultrafiltration) and is amenable to upscaling with continuous photobioreactor cultivation. Our goal was to take advantage of the modulable surface properties of the graphitic matrix by optimizing its interactions with marennine. As such, the effects of organic modifiers, pH and reducing agents were studied. With this improvement on marennine purification, we achieved altogether the isolation of a fucoidan-related, sulfated polysaccharide from blue water. Characterization of the polysaccharides fraction suggests that roughly half of UV-absorbing compounds could be isolated from the marennine crude extracts. The identification of sulfated polysaccharides could be a major breakthrough for marennine purification, providing targeted isolation techniques. Likewise, the added value of Haslea ostrearia and the role of polysaccharides in previous marennine chemical characterization and bioactivity studies remain to be determined.
机译：该化合物“玛永宁”是由底栖微藻菌群岛芥末植物产生的蓝绿色颜料，病原性降低了对某些细菌的致病活动，以及作为海鲜产业中天然色素的有希望的潜力。经过几十年的研究，该化合物的化学家族仍然尚不清楚，主要是因为通过在玛瑙分离株的共萃取化合物存在损害结构研究。为了提高玛瑙提取物的纯度，我们开发了一种使用石墨固定阶段的新型提取方法，其使用串联超滤提供了通过前一级的各种优势。我们的方法更快，更通用，提供更好的粗产率（66％，相比超滤的57％），并且可与连续的光生物反应器培养升高。我们的目标是通过优化与玛永宁的相互作用来利用石墨矩阵的可修改表面特性。因此，研究了有机改性剂，pH和还原剂的影响。随着玛永宁净化的改善，我们完全实现了来自蓝色水的岩藻糖相关的硫酸化多糖的分离。多糖级分的表征表明，大约一半的UV吸收化合物可以从玛永宁粗提取物中分离。硫酸化多糖的鉴定可能是玛永宁纯化的重大突破，提供靶向分离技术。同样地，哈希亚欧洲血糖的附加值和多糖在先前的玛永化学表征和生物活性研究中的作用仍然确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号