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首页> 美国卫生研究院文献>Materials >Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
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Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants

机译：新型生物相容性ZR基合金具有低杨氏模量和生物医学植入物的磁性敏感性

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The microstructure, mechanical properties, magnetic susceptibility, electrochemical corrosion performance, in vitro cell compatibility and blood consistency of Zr-16Nb-xTi (x = 0, 4, 8, 12 and 16 wt.%) materials were investigated as potential materials for biomedical implants. X-ray diffraction (XRD) and Transmission electron microscopy (TEM) analyses revealed the secondary phase martensite α’ formed during the quenching process. The phase composition contained metastable β and martensite α’, resulting from Ti addition. These phase constitutions were the main causes of a low Young’s modulus and magnetic susceptibility. The in vitro cytocompatibility analysis illustrated that the MG63 cells maintained high activity (from 91% to 97%) after culturing in Zr-16Nb-xTi extraction media for 12 days due to the high internal biocompatibility of Zr, Nb and Ti elements, as well as the optimal corrosion resistance of Zr-16Nb-xTi. On the basis of Inductively coupled plasma optical emission spectrometry (ICP-OES) ion release studies, the concentration of Zr, Nb and Ti was noted to reach the equipment detective limit of 0.001 mg/L, which was much lower than pure Ti. With respect to the corrosion behavior in Hank’s solution, Zr-16Nb-16Ti displayed superior properties, possessing the lowest corrosion current density and widest passivation region, attributed to the addition of Ti. The blood compatibility test illustrated that the Zr-16Nb-xTi materials were nonhemolytic, and the platelets maintained a spherical shape, with no aggregation or activation on Zr-16Nb-xTi. Overall, Ti addition has obvious effects on the developed Zr-16Nb-xTi alloys, and Zr-16Nb-4Ti exhibited low magnetic susceptibility, low modulus, good biocompatibility and proper corrosion properties, demonstrating the potential of use as implant biomaterials.
机译：ZR-16NB-XTI（X = 0,4,8,12和16重量％）的微观结构，机械性能，磁化率，电化学腐蚀性能，体外细胞相容性和血液稠度作为生物医学的潜在材料研究植入物。 X射线衍射（XRD）和透射电子显微镜（TEM）分析显示在淬火过程中形成的二次相马氏体α'。相组合物含有亚稳β和马氏体α'，由Ti添加引起。这些阶段构成是较小杨氏模量和磁化率的主要原因。体外细胞膜相容性分析表明，由于Zr，Nb和Ti元素的高内部生物相容性，Mg63细胞在Zr-16NB-XTI提取介质中培养12天后，Mg63细胞保持高活性（从91％至97％）作为ZR-16NB-XTI的最佳耐腐蚀性。在电感耦合等离子体发射光谱法（ICP-OES）离子释放研究的基础上，注意到Zr，Nb和Ti的浓度，以达到0.001mg / L的设备侦探极限，但远低于纯Ti。关于Hank的解决方案中的腐蚀行为，ZR-16NB-16TI显示出具有最低腐蚀电流密度和最宽的钝化区域的优异性能，其归因于添加TI。血液相容性测试说明ZR-16NB-XTI材料是非溶解的，并且血小板保持球形，没有聚集或激活ZR-16NB-XTI。总体而言，Ti添加对开发的ZR-16NB-XTI合金具有明显的影响，ZR-16NB-4TI对低磁性敏感性，低模量，良好的生物相容性和适当的腐蚀性，展示了用作植入物生物材料的潜力。

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