• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Nanomaterials >Design and Synthesis of Multi-Functional Superparamagnetic Core-Gold Shell Nanoparticles Coated with Chitosan and Folate for Targeted Antitumor Therapy
【2h】

Design and Synthesis of Multi-Functional Superparamagnetic Core-Gold Shell Nanoparticles Coated with Chitosan and Folate for Targeted Antitumor Therapy

机译：用壳聚糖和甲状腺瘤涂覆的多功能超顺磁性芯金壳纳米粒子的设计与合成靶向抗肿瘤治疗

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A dual-targeting nanomedicine composed of pH-sensitive superparamagnetic iron oxide core-gold shell SPION@Au, chitosan (CS), and folate (FA) was developed as a doxorubicin (DOX) antitumor medication. Microemulsion was used for preparation and cross-linking conjugation. The characteristics of the designed nanocomposite were studied using atomic force microscopy (AFM), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction, UV-visible spectroscopy, Zeta potential and vibrating sample magnetometry (VSM), and Fourier transform infrared spectroscopy. The prepared SPION@Au-CS-DOX-FA nanoparticles (NPs) were spherical with an average diameter of 102.6 ± 7 nm and displayed an elevated drug loading behavior and sustained drug release capacity. The SPION@Au-CS-DOX-FA NPs revealed long term anti-cancer efficacy due to their cytotoxic effect and apoptotic inducing efficiency in SkBr3 cell lines. Additionally, Real-time PCR outcomes significantly showed an increase in BAK and BAX expression and a decrease in BCL-XL and BCL-2. In vivo results revealed that SPION@Au significantly decreased the tumor size in treated mice through magnetization. In conclusion, prepared SPION@Au-CS-DOX-FA could be a beneficial drug formulation for clinical breast cancer treatment.
机译：由pH敏感的超顺磁性氧化铁核心 - 金壳氧化物核心 - 金壳Spion @ au，壳聚糖（cs）和叶酸（fa）组成的双靶向纳米edicicine作为多柔比星（dox）抗肿瘤药物。微乳液用于制备和交联缀合。使用原子力显微镜（AFM），透射电子显微镜（TEM），扫描电子显微镜（SEM），X射线衍射，UV可见光谱，Zeta电位和振动样品磁体（VSM）进行了设计纳米复合材料的特性。和傅里叶变换红外光谱。制备的SPION @ AU-CS-DOX-FA纳米颗粒（NPS）是球形的，平均直径为102.6±7nm，呈现出升高的药物载荷行为和持续的药物释放能力。 SPION @ AU-CS-DOX-FA NPS由于其细胞毒性效应和SKBR3细胞系中的凋亡诱导效率而显示了长期抗癌效能。另外，实时PCR结果显着显示了Bak和Bax表达的增加和Bcl-XL和Bcl-2的降低。在体内结果表明，Spion @ Au通过磁化显着降低治疗小鼠中的肿瘤大小。总之，制备的SPION @ AU-CS-DOX-FA可以是临床乳腺癌治疗的有益药物制剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号