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Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

机译：包封氯萘乳液的全氟聚醚纳米乳剂用于缺氧肿瘤的慢性动力学和光动力学治疗

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摘要

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.
机译：Sonodynamic治疗（SDT）已成为癌症治疗的重要态度。 SDT利用超声激发，其克服了深肿瘤中光穿透的局限性，如光动力治疗（PDT）所遇到的，它使用光学激励。使用相同敏化剂药物的这些方式的比较研究可以提供对其效果的评估。然而，SDT和PDT的效率在缺氧肿瘤环境中低，这限制了它们的应用。在这项研究中，我们报告了一种分层纳米型，其含有食品和药物管理局（FDA）批准的敏化剂氯氯，E6和独特稳定的高负载能量氧载体，全氟聚醚。该氧载体没有可测量的细胞毒性。它提供氧气来克服缺氧，同时促进SDT和PDT的效率。此外，我们对整个组织深度的肿瘤处理的SDT和PDT的效率相比分析。我们的研究表明，PDT和SDT的优点可以组合成单一多功能纳米片，这在缺氧环境中运作良好，并克服了每种方式的局限性。通过光通过光的深层组织渗透的组合用于选择性处理单细胞的选择性处理将显着提高治疗应用的范围。

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