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Topical Administration of Terpenes Encapsulated in Nanostructured Lipid-Based Systems

机译：封装在纳米结构脂质系系统中的典型萜烯

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摘要

Terpenes are a group of phytocompounds that have been used in medicine for decades owing to their significant role in human health. So far, they have been examined for therapeutic purposes as antibacterial, anti-inflammatory, antitumoral agents, and the clinical potential of this class of compounds has been increasing continuously as a source of pharmacologically interesting agents also in relation to topical administration. Major difficulties in achieving sustained delivery of terpenes to the skin are connected with their low solubility and stability, as well as poor cell penetration. In order to overcome these disadvantages, new delivery technologies based on nanostructures are proposed to improve bioavailability and allow controlled release. This review highlights the potential properties of terpenes loaded in several types of lipid-based nanocarriers (liposomes, solid lipid nanoparticles, and nanostructured lipid carriers) used to overcome free terpenes’ form limitations and potentiate their therapeutic properties for topical administration.
机译：Terpenes是一组植物化合物，由于其在人类健康中的重要作用而被用作医学数十年。到目前为止，他们已被检查用于治疗目的，作为抗菌，抗炎，抗肿瘤剂，并且这类化合物的临床潜力在与局部给药方面也是药理学上的源代理的源。实现持续交付Terpenes对皮肤的主要困难与其低溶解度和稳定性，以及细胞渗透率不佳。为了克服这些缺点，提出了基于纳米结构的新递送技术来改善生物利用度并允许受控释放。本综述突出了诸如脂质基纳米载体（脂质体，固体脂质纳米粒子和纳米结构脂质载体）的萜烯的潜在特性，用于克服自由萜烯的形状限制，并使其治疗其治疗性能进行局部给药。

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