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Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents

机译:低粘附在注射用直效抗病毒剂治疗的药物的人们中实现高HCV治愈率

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摘要

We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.
机译:我们测量了通过电子泡罩包装的丙型肝炎病毒(HCV)依从性,用于145人在美沙酮计划中注射现场治疗的药物。总体持续的病毒学反应(SVR)率为96%(95%CI,91%-98%),总体日常粘附量为78%(95%CI,76%-81%)。实现至少50%遵守的参与者的总体SVR率为99%,每次5%依从性间隔> 50%遵守依赖率至少90%。次优依从性仍可能导致直接抗病毒时代治愈。

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