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首页> 美国卫生研究院文献>Neurologia medico-chirurgica >Relationship between Deep White Matter Hyperintensities on Magnetic Resonance Imaging and Postoperative Cognitive Function Following Clipping of Unruptured Intracranial Aneurysm
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Relationship between Deep White Matter Hyperintensities on Magnetic Resonance Imaging and Postoperative Cognitive Function Following Clipping of Unruptured Intracranial Aneurysm

机译：磁共振成像与术后认知功能的深白物质高原与颅内动脉瘤夹持后的关系

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To evaluate the effects on cognitive function of deep white matter hyperintensities (DWMHs) on magnetic resonance imaging (MRI) in patients treated surgically for unruptured intracranial aneurysms (UIAs). The subjects were 106 patients in whom a Wechsler adult intelligence scale-revised (WAIS-R) examination was performed 1 week before and 1 month after clipping surgery for asymptomatic UIAs. DWMH severity was evaluated on preoperative MR images by Fazekas scale, as follows: none (absence), mild (punctate foci), moderate (beginning confluence of foci), or severe (large confluent areas). A decrease of 7 or more points in intelligence quotient (IQ) postoperatively was considered deterioration. Fazekas score was none in 41 (none group), mild in 42 (mild group), moderate in 21, and severe in 2 patients (moderate/severe group). Patient characteristics, surgical factors, IQ change, and abnormal findings on postoperative MRI were compared among the groups. Although there was no statistically significant deterioration in IQ postoperatively in any group, the percentage of deteriorated patients was significantly higher in the moderate/severe group (34.8%) than in the other groups (4.9% in the none group, 7.1% in the mild group; p <0.01, p <0.05, respectively). Brain injury was observed more frequently on postoperative MR images in the moderate/severe group (17.4%) compared with the none group (2.4%; p = 0.052). The presence of moderate/severe DWMHs was an independent prognostic factor for postoperative cognitive dysfunction. In conclusion, the presence of moderate/severe DWMHs was a prognostic factor for postoperative cognitive dysfunction after surgery for UIAs.
机译：为了围绕颅内动脉瘤（UIA）治疗患者磁共振成像（DWMH）对磁共振成像（MRI）对磁共振成像（MRI）的影响。该受试者是106名患者，其中一名巫术成人智能规模修订（WAIS-R）检查在剪切手术前1周，为无症状UIA剪切手术。 DWMH严重程度通过Fazekas Scale评估术前MR图像，如下：无（缺席），轻度（点状焦点），中等（焦点的开始汇合），或严重（大汇合区域）。术后智力（IQ）中的7个或更多点减少了7个或更多个点被认为是恶化的。 Fazekas得分在41（无组）中没有，42例（轻度组），21例，21例，2例患者严重（中等/严重）。在群体中比较了患者特征，手术因素，智商改变和术后MRI的异常发现。虽然在任何组术后诊断中没有统计学上显着恶化，但在中/严重组（34.8％）中，劣化患者的百分比显着高于其他组（无组4.9％，温和的7.1％组; P <0.01，P <0.05）。与无组（17.4％）的术后MR图像更频繁地观察到脑损伤，与无组（2.4％; p = 0.052）。中度/严重DWMH的存在是术后认知功能障碍的独立预后因素。总之，适度/严重DWMH的存在是UIA手术后术后认知功能障碍的预后因素。

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