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首页> 美国卫生研究院文献>The Pan African Medical Journal >Field investigation and response to a vaccine-derived poliovirus pre-tOPV switch in Southwest Nigeria October 2015
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Field investigation and response to a vaccine-derived poliovirus pre-tOPV switch in Southwest Nigeria October 2015

机译：对尼日利亚西南部的疫苗衍生的Poliovirus预先开关的现场调查和反应2015年10月

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A vaccine-derived poliovirus (VDPV) was isolated in an acute flaccid paralysis (AFP) case reported from Ile-Ife, in Osun state, Southwest Nigeria. We investigated the epidemiological characteristics of the polio event and described the immediate public health response that followed. We interviewed the primary caregiver of the case and conducted active case searches for additional AFP cases in the communities in Ife East Local Government Area (LGA) of Osun state. Stool samples of contacts and non-contacts were collected and sent for laboratory investigation. A public health response with mass supplementary immunization in the affected areas followed immediately in the ward the case was located in October 2015. Also, we reviewed the administrative record of the oral polio vaccine (OPV) coverage in the LGA in the previous four years. The VDPV case was a female, one-month-old child with adequate vaccination history for her age. However, the environment of the child was relatively filthy with inappropriate facilities. Laboratory reports from contact samples were negative for VDPV or any polio isolates. A missed AFP case was found from active case searches and a high proportion of under-five children was immunized with tOPV. The OPV3 administrative coverage in the LGA peaked in 2014 (103%) and dropped in 2015 (67%). Efforts directed toward improving environmental hygiene in households and improving OPV coverage in subsequent routine and supplementary immunization are suggested.
机译：疫苗衍生的脊髓灰质炎病毒（VDPV）分离在尼日利亚西南部的Osun州的Ile-Ife报告的急性皮脂瘫痪（AFP）案件中。我们调查了脊髓灰质炎活动的流行病学特征，并描述了所遵循的直接公共卫生反应。我们采访了案件的主要护理人，并对OSUN州的IFE东部地方政府区域（LGA）的社区进行了额外的AFP案件。收集并送出右接触和非接触的粪便样本，以进行实验室调查。在病房中立即在案件中立即在受影响地区进行大规模补充免疫的公共卫生反应，案件于2015年10月。此外，我们审查了前四年LGA中的口头脊髓灰质炎疫苗（OPV）覆盖范围的行政记录。 VDPV案例是一名女性，一个月大的孩子，为她的年龄具有足够的疫苗接种历史。然而，孩子的环境比较肮脏，不适当的设施。来自接触样品的实验室报告对VDPV或任何脊髓灰质炎分离株为阴性。从积极的案例搜索中发现了错过的法令案案例，并且用TopV免疫了大量的下半年儿童。 LGA的OPV3行政覆盖范围于2014年（103％）达到达到（103％），并在2015年下降（67％）。提出了努力改善家庭环境卫生的努力，提高随后的常规免疫和补充免疫中的OPV覆盖。

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