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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Combined Intervention of Physical Activity Aerobic Exercise and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study
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Combined Intervention of Physical Activity Aerobic Exercise and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study

机译：联合运动干预有氧运动和认知运动干预预防轻度认知障碍患者的认知功能下降：一项随机对照临床研究

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This study aimed to investigate the association between a dual-task intervention program and cognitive and physical functions. In a randomized controlled trial, we enrolled 49 individuals with MCI. The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the MMSE and modified Alzheimer’s disease Assessment Scale-Cognitive Subscale (ADAS-Cog), both at baseline and at 3 months follow-up. The program comprised physical activity and behavior modification, aerobic exercise, and a cognitive and exercise combined intervention program. Analysis of the subjects for group-time interactions revealed that the exercise group exhibited a significantly improved ADAS-Cog, working memory, and executive function. Total physical activity levels were associated with improvements in working memory function and the modified ADAS-Cog score, and the associations were stronger for daily moderate intensity activity than for daily step count. The 24-week combined intervention improved cognitive function and physical function in patients with MCI relative to controls. Encouraging participants to perform an additional 10 min of moderate physical activity under supervision, during ongoing intervention, may be more beneficial to prevent cognitive decline and improve exercise adherence.
机译：这项研究旨在调查双任务干预计划与认知和身体功能之间的关联。在一项随机对照试验中，我们招募了49名MCI患者。 MCI诊断基于痴呆症专家进行的临床访谈进行的医学评估。神经心理学家根据标准化方法（包括MMSE和改良的阿尔茨海默氏病评估量表-认知子量表（ADAS-Cog））在基线和随访3个月时进行了认知评估。该计划包括体育锻炼和行为改变，有氧运动以及认知和运动相结合的干预计划。对受试者进行小组时间互动的分析表明，运动组的ADAS-Cog，工作记忆和执行功能显着改善。总的身体活动水平与工作记忆功能的改善和改良的ADAS-Cog评分相关，并且与日常步数相比，每日中等强度活动的关联性更强。与对照组相比，为期24周的联合干预改善了MCI患者的认知功能和身体功能。在正在进行的干预过程中，鼓励参与者在监督下进行额外的10分钟中等锻炼，可能对预防认知能力下降和改善运动依从性更为有益。

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