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Low Carb and Ketogenic Diets Increase Quality of Life Physical Performance Body Composition and Metabolic Health of Women with Breast Cancer

机译:低碳水化合物和酮培养饮食提高了乳腺癌妇女的生活质量身体性能身体成分和妇女的代谢健康

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摘要

Breast cancer (BC) patients often ask for a healthy diet. Here, we investigated a healthy standard diet (SD), a low carb diet (LCD), and a ketogenic diet (KD) for BC patients during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining inpatient and outpatient phases for 20 weeks. Female BC patients (n = 152; mean age 51.7 years) could select their diet. Data collected were: Quality of life (QoL), spiroergometry, body composition, and blood parameters. In total 30, 92, and 30 patients started the KD, LCD, and SD, respectively. Of those, 20, 76, and 25 completed the final examination. Patients rated all diets as feasible in daily life. All groups enhanced QoL, body composition, and physical performance. LCD participants showed the most impressive improvement in QoL aspects. KD participants finished with a very good physical performance and muscle/fat ratio. Despite increased cholesterol levels, KD patients had the best triglyceride/high-density lipoprotein (HDL) ratio and homeostatic model assessment of insulin resistance index (HOMA-IR). Most metabolic parameters significantly improved in the LCD group. SD participants ended with remarkably low cholesterol levels but did not improve triglyceride/HDL or HOMA-IR. In conclusion, both well-defined KDs and LCDs are safe and beneficial for BC patients and can be recommended during the rehabilitation phase.
机译:乳腺癌(BC)患者经常要求健康饮食。在这里,我们在康复阶段调查了BC患者的健康标准饮食(SD),低碳饮食(LCD)和酮饮食(KD)。 Kolibri是一个开放标签的非随机性一类营养干预试验,将住院患者和门诊阶段组合20周。女性BC患者(n = 152;平均51.7岁)可以选择他们的饮食。收集的数据是:生活质量(QOL),螺旋计,身体成分和血液参数。总共30,92和30名患者分别开始KD,LCD和SD。其中20,76和25次完成了最终检查。患者在日常生活中评定所有饮食。所有组都增强了QoL,身体成分和物理性能。液晶显示器展示了QOL方面最令人印象深刻的改善。 KD参与者以非常好的物理性能和肌肉/脂肪比完成。尽管胆固醇水平升高,但KD患者具有最佳的甘油三酯/高密度脂蛋白(HDL)比率和稳态模型评估胰岛素抵抗指数(HOMA-IR)。 LCD组大多数代谢参数显着改善。 SD参与者以极低的胆固醇水平结束,但未改善甘油三酯/ HDL或HOMA-IR。总之,对于BC患者来说,明确定义的KDS和LCD都是安全和有益的,并且可以在康复阶段建议。

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