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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Clinical Value of Whole Blood Procalcitonin Using Point of Care Testing Quick Sequential Organ Failure Assessment Score C-Reactive Protein and Lactate in Emergency Department Patients with Suspected Infection
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Clinical Value of Whole Blood Procalcitonin Using Point of Care Testing Quick Sequential Organ Failure Assessment Score C-Reactive Protein and Lactate in Emergency Department Patients with Suspected Infection

机译：急诊科疑似感染患者使用即时检验连续器官功能衰竭快速评估评分C反应蛋白和乳酸对全血降钙素的临床价值

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We investigated the clinical value of whole blood procalcitonin using point of care testing, quick sequential organ failure assessment score, C-reactive protein and lactate in emergency department patients with suspected infection and assessed the accuracy of the whole blood procalcitonin test by point-of-care testing. Participants were randomly selected from emergency department patients who complained of a febrile sense, had suspected infection and underwent serum procalcitonin testing. Whole blood procalcitonin levels by point-of-care testing were compared with serum procalcitonin test results from the laboratory. Participants were divided into two groups—those with bacteremia and those without bacteremia. Sensitivity, specificity, positive predictive value, negative predictive value of procalcitonin, lactate and Quick Sepsis-related Organ Failure Assessment scores were investigated in each group. Area under receiving operating curve of C-reactive protein, lactate and procalcitonin for predicting bacteremia and 28-day mortality were also evaluated. Whole blood procalcitonin had an excellent correlation with serum procalcitonin. The negative predictive value of procalcitonin and lactate was over 90%. Area under receiving operating curve results proved whole blood procalcitonin to be fair in predicting bacteremia or 28-day mortality. In the emergency department, point-of-care testing of whole blood procalcitonin is as accurate as laboratory testing. Moreover, procalcitonin is a complementing test together with lactate for predicting 28-days mortality and bacteremia for patients with suspected infection.
机译：我们使用护理点测试，快速连续器官衰竭评估评分，C反应蛋白和乳酸对疑似感染的急诊患者进行了全血降钙素的临床价值调查，并通过即时点评估了全血降钙素测试的准确性护理测试。从急诊科的患者中随机选择参与者，这些患者抱怨有发热感，怀疑感染并接受血清降钙素原测试。将即时检验得出的全血降钙素水平与实验室的血清降钙素检测结果进行了比较。参加者分为两组-有菌血症的人和没有菌血症的人。对每组的降钙素原，乳酸盐和快速败血症相关器官衰竭评估评分进行敏感性，特异性，阳性预测值，阴性预测值的调查。还评估了C反应蛋白，乳酸和降钙素的工作曲线下的面积，以预测菌血症和28天死亡率。全血降钙素与血清降钙素有极好的相关性。降钙素原和乳酸盐的阴性预测值超过90％。接收操作曲线结果下的面积证明全血降钙素在预测菌血症或28天死亡率方面是公平的。在急诊科，全血降钙素的即时护理检测与实验室检测一样准确。此外，降钙素原与乳酸一起是一项补充测试，可预测可疑感染患者的28天死亡率和菌血症。

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