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Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

机译：利用深共晶溶剂和分析方法的创新提取技术用于植物材料中天然生物活性化合物的分离及分析

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.
机译：食品，制药和化妆品行业在天然存在的生物活性化合物或次生植物代谢物中越来越兴趣也导致对开发新的和更有效的分析和隔离技术的日益增长的需求。来自植物材料的生物活性化合物的提取始终是挑战，伴随着对最终产品的越来越严格的控制要求和对环境保护的兴趣。然而，在这个方向上进行了巨大的努力，今天已经采用了相当数量的创新提取技术，采用绿色，环保溶剂开发。这些溶剂包括深的共晶溶剂（DES）及其天然等同物，天然深度共晶溶剂（NADE）。由于其可调节的物理化学性质及其绿色特性，预计DES / NADE可能是未来最广泛使用的溶剂，不仅在提取过程中，而且在其他研究领域如催化，电化学或有机合成等。因此，本综述提供了与可创新的提取技术相结合的使用DES / NADE的最新系统概述，用于从各种植物材料中分离生物活性化合物。该领域的主题通过详细搜索了WOS（科学网）的详细搜索，这导致了在过去三年中对生物活性化合物的DES / NADES超过100种原始研究论文。除了从植物中分离生物活性化合物，还提出并讨论了不同的分析方法。

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