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Component-Resolved Diagnosis of Hazelnut Allergy in Children

机译：儿童榛子过敏的组分解决诊断

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Hazelnuts commonly elicit allergic reactions starting from childhood and adolescence, with a rare resolution over time. The definite diagnosis of a hazelnut allergy relies on an oral food challenge. The role of component resolved diagnostics in reducing the need for oral food challenges in the diagnosis of hazelnut allergies is still debated. Therefore, three electronic databases were systematically searched for studies on the diagnostic accuracy of specific-IgE (sIgE) on hazelnut proteins for identifying children with a hazelnut allergy. Studies regarding IgE testing on at least one hazelnut allergen component in children whose final diagnosis was determined by oral food challenges or a suggestive history of serious symptoms due to a hazelnut allergy were included. Study quality was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Eight studies enrolling 757 children, were identified. Overall, sensitivity, specificity, area under the curve and diagnostic odd ratio of Cor a 1 sIgE were lower than those of Cor a 9 and Cor a 14 sIge. When the test results were positive, the post-test probability of a hazelnut allergy was 34% for Cor a 1 sIgE, 60% for Cor a9 sIgE and 73% for Cor a 14 sIgE. When the test results were negative, the post-test probability of a hazelnut allergy was 55% for Cor a 1 sIgE, 16% for Cor a9 sIgE and 14% for Cor a 14 sIgE. Measurement of IgE levels to Cor a 9 and Cor a 14 might have the potential to improve specificity in detecting clinically tolerant children among hazelnut-sensitized ones, reducing the need to perform oral food challenges.
机译：榛子通常从儿童和青春期开始引发过敏反应，随着时间的推移，罕见的分辨率。榛子过敏的明确诊断依赖于口腔食物挑战。组件已解决的诊断在减少对榛子过敏诊断中对口腔食物挑战的需要的作用仍然讨论。因此，系统地搜索了三种电子数据库，以研究榛子蛋白特异性 - IgE（SiGe）对榛子过敏的儿童的诊断准确性研究。包括对至少一种榛子过敏原组分在最终诊断的榛子过敏原组分的研究，或者包括口服食物挑战或由于榛子过敏由于榛子过敏的严重症状的提示史。通过诊断准确性研究-2工具的质量评估评估研究质量。鉴定了八项注册757名儿童的研究。总体而言，曲线下的敏感性，特异性，面积，COR 1 SiGe的曲线和诊断奇数均低于COR A 9和COR 14 SiGe的诊断比。当测试结果为阳性时，Cor Aige的榛子过敏的后测试概率为34％，对于Cor Aige的60％，对于Cor Aige的73％，为73％。当测试结果为阴性时，榛子过敏的后测试概率为COR 1 SiGe为55％，对于Cor Aige的16％，Cor Aige为14％的14％。 IgE水平对COR A 9和COR 14的测量可能有可能提高检测榛子致敏的儿童的特异性，从而减少了进行口腔食物挑战的需要。

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