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Divergent trajectories of cellular bioenergetics intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness

机译：幸存者中的细胞生物能诊中间新陈代谢和全身氧化还原状态的分歧轨迹和危重疾病的非幸存者

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摘要

Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiting the efficacy of modern life-support.

机译：许多病程导致多器官衰竭，被认为是受损细胞生物生物能力状态的直接后果。这种表型的性质与其与生存的相关性都很好地理解，限制了现代寿命支持的功效。

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期刊名称 Redox Biology
作者
Helen T. McKenna; Katie A. OBrien; Bernadette O. Fernandez; Magdalena Minnion; Adam Tod; Ben D. McNally; James A. West; Julian L. Griffin; Michael P. Grocott; Michael G. Mythen; Martin Feelisch; Andrew J. Murray; Daniel S. Martin;
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年(卷),期 2021(-1),-1
年度 2021
页码 -1
总页数 15
原文格式 PDF
正文语种
中图分类生物学;
关键词
Critical illness; Stress physiology; Energy metabolism; Mitochondria; Redox signaling; Oxidative stress;

机译：危重疾病;应激生理;能量代谢;线粒体;氧化还原信号;氧化应激;

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专利

1. Endocrine measurements in survivors and non-survivors from critical illness. [J] . Ray DC, Macduff A, Drummond GB, Intensive care medicine . 2002,第9期

机译：重大疾病幸存者和非幸存者的内分泌测量。
2. Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study. [J] . Pachot A, Lepape A, Vey S, Immunology Letters . 2006,第1期

机译：幸存者和非幸存者休克患者的全身转录分析：一项初步研究。
3. Differences in Fat Metabolism Between Predicted Survivors And Non-Survivors of Faecal Peritonitis [J] . A Kleyman, W Khaliq, S Neugebauer, Intensive Care Medicine Experimental . 2015,第S1期

机译：粪便性腹膜炎的预测幸存者与非幸存者之间的脂肪代谢差异
4. Contribution of Glutathione Redox Imbalance to Bioenergetics Status in Alzheimer Mouse Model [C] . Cheng Zhang, Magdalena Circu, James Spaulding, World biomaterials congress . 2012

机译：谷胱甘肽氧化还原失衡对阿尔茨海默病小鼠模型中生物能状态的贡献。
5. Transcriptional Profiling and Regulation in Survivors of Critical Illness with Muscle Weakness and Meta-analysis Across Human Muscle Diseases [D] . Walsh, Christopher J. 2019

机译：在人类肌肉疾病的肌肉弱点和荟萃分析中的危重疾病幸存者转录分析和调节
6. Survivors Versus Non-Survivors Postburn: Differences In Inflammatory and Hypermetabolic Trajectories [O] . Marc G. Jeschke, Gerd G. Gauglitz, Celeste C. Finnerty, -1

机译：烧伤后幸存者与非幸存者：炎性和代谢亢进轨迹的差异
7. Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness [O] . Helen T. McKenna, Katie A. OBrien, Bernadette O. Fernandez, 2021

机译：幸存者中的细胞生物能诊，中间新陈代谢和全身氧化还原状态的分歧轨迹和危重疾病的非幸存者

Divergent trajectories of cellular bioenergetics intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness

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