首页> 美国卫生研究院文献>Journal of Cerebral Blood Flow Metabolism >Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels
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Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

机译:val66met BDNF多态性状态或血液BDNF水平不会影响人的脑5-HT2A受体和血清素转运蛋白的结合

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摘要

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT2A) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT2A receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT2A receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT2A or SERT binding.
机译:最近的研究提出了脑源性神经营养因子(BDNF)val66met多态性与血清素系统之间的相互关系。在这项研究中,我们调查了健康受试者中BDNF val66met多态性或血液BDNF水平是否与脑5-羟色胺2A(5-HT2A)受体或血清素转运蛋白(SERT)结合有关。在val / val和met携带者之间,没有发现5-HT2A受体或SERT结合的统计学显着差异,也没有发现与SERT结合或5-HT2A受体结合相关的血液BDNF值。总之,val66met BDNF多态性状态与血清素能系统的变化无关。此外,血液中的BDNF水平与5-HT2A或SERT结合均不相关。

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