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首页> 美国卫生研究院文献>Journal of Cerebral Blood Flow Metabolism >Correspondence between altered functional and structural connectivity in the contralesional sensorimotor cortex after unilateral stroke in rats: a combined resting-state functional MRI and manganese-enhanced MRI study
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Correspondence between altered functional and structural connectivity in the contralesional sensorimotor cortex after unilateral stroke in rats: a combined resting-state functional MRI and manganese-enhanced MRI study

机译：大鼠单侧卒中后对侧感觉运动皮层功能和结构连接性改变的对应关系：静息状态功能磁共振成像和锰增强磁共振成像研究

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摘要

This study shows a significant correlation between functional connectivity, as measured with resting-state functional magnetic resonance imaging (MRI), and neuroanatomical connectivity, as measured with manganese-enhanced MRI, in rats at 10 weeks after unilateral stroke and in age-matched controls. Reduced interhemispheric functional connectivity between the contralesional primary motor cortex (M1) and ipsilesional sensorimotor cortical regions was accompanied by a decrease in transcallosal manganese transfer from contralesional M1 to the ipsilesional sensorimotor cortex after a large unilateral stroke. Increased intrahemispheric functional connectivity in the contralesional sensorimotor cortex was associated with locally enhanced neuroanatomical tracer uptake, which underlines the strong link between functional and structural reorganization of neuronal networks after stroke.
机译：这项研究表明，在单侧卒中后10周和年龄匹配的对照组中，静息状态功能磁共振成像（MRI）测量的功能连通性与锰增强MRI测量的神经解剖学连通性之间存在显着相关性。对侧主要运动皮层（M1）和同侧感觉运动皮层区域之间的半球间功能连通性降低，伴随着大单侧卒中后从对侧M1到对感觉运动皮层的跨壁锰转移减少。对侧感觉运动皮层半球内功能连接性的增加与局部神经解剖学示踪剂摄取的增加有关，这突显了中风后神经元网络的功能和结构重组之间的紧密联系。

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