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首页> 美国卫生研究院文献>Journal of Cerebral Blood Flow Metabolism >Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain
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Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain

机译：统计参数映射显示正常脑中Tc-99m ECD和Tc-99m HMPAO SPECT的不对称摄取

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摘要

Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.
机译：Tc-99m半胱氨酸乙酯（ECD）和Tc-99m六甲基丙烯胺肟（HMPAO）通常用于各种神经系统疾病的单光子发射计算机断层扫描（SPECT）研究。尽管这些示踪剂在诊断和指导神经系统疾病的治疗方面非常有帮助，但是描述这些示踪剂在正常静息大脑中的分布和侧向性的数据仍然有限。定量功能影像学的进展表明，使用对照组的静息研究作为基线来解释脑灌注的生理波动具有重要价值。在这里，我们报告了30例静息Tc-99m ECD SPECT扫描和14例静息Tc-99m HMPAO扫描的正常志愿者的结果，这些志愿者没有神经系统疾病的病史。使用感兴趣的区域和统计参数映射对扫描进行分析，并横向比较（左与右），以及年龄，性别和惯用性。结果显示正常对照中明显不对称的区域会影响大脑半球的广泛区域，但最明显的表现在上颞叶区域和额叶。该结果对于在神经病患者评估中使用正常对照SPECT图像具有重要意义。

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