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As (and when) you like it: on-demand phospholipid synthesis drives phagophore expansion during autophagy

机译：as（当时）您喜欢它：按需磷脂合成在自噬过程中推动吞噬膨胀

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摘要

A key feature of macroautophagy/autophagy is the formation of a transient de novo compartment called the phagophore, which envelops cytoplasmic material, ultimately enclosing it within an autophagosome, allowing it to be targeted for degradation. Schütter et al describe a novel mechanism that spatiotemporally coordinates phospholipid synthesis to drive phagophore expansion and autophagosome formation. These authors show that during starvation, fatty acids (FAs) are channeled into phospholipid synthesis, and the newly synthesized lipids are directed toward autophagosome biogenesis.

机译：宏观摄入/自噬的一个关键特征是形成瞬态De Novo隔室，称为植物，其包围细胞质材料，最终将其封闭在自噬体内，使其旨在用于降解。 Schütter等描述了一种新的机制，即发短发短的磷脂合成以驱动噬菌体膨胀和自噬体形成。这些作者表明，在饥饿期间，脂肪酸（FAS）被引导到磷脂合成中，并且新合成的脂质被引导朝向自噬体生物发生。

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期刊名称 Autophagy
作者
Shree Padma Metur; Daniel J. Klionsky;
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作者单位

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年(卷),期 2020(16),5
年度 2020
页码 779–781
总页数 3
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词

机译：自噬体;脂肪酸;脂质;溶酶体;膜;应力;液泡;

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专利

1. Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy [J] . Schuetter Maximilian, Giavalisco Patrick, Brodesser Susanne, Cell . 2020,第1期

机译：局部脂肪酸窜入磷脂合成中，在自噬过程中推动吞噬膨胀
2. 2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas [J] . Viswanath Pavithra, Radoul Marina, Luis Izquierdo-Garcia Jose, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2018,第9期

机译：2-羟基戊酸介导的内质网的自噬导致突变体IDH1 GLIMAS中磷脂生物合成的不寻常下调
3. Forms, Crosstalks, and the Role of Phospholipid Biosynthesis in Autophagy [J] . Leanne Pereira, John Paul Girardi, Marica Bakovic International Journal of Cell Biology . 2012,第1期

机译：形式，串扰以及磷脂生物合成在自噬中的作用
4. A Phospholipid Prodrug of Chlorambucil for Cancers: Design, Synthesis, and Primary Evaluation [C] . Shih-Kwang Wu, Chin-Lu Tseng, Ting-Gung Chang Annual meeting exposition of the Controlled Release Society . 2010

机译：苯丁酸氮芥用于癌症的磷脂前药：设计，合成和初步评估
5. Chapter 1: (I) Use of chain-modified phospholipids to determine water content of bilayers. (II) Ion transport across bilayers of chain-modified phospholipids. Chapter 2: Synthesis, catalytic properties of and studies toward electron transport by copper-complexed lipids. [D] . Aikens, Patricia Ann Elizabeth. 1990

机译：第1章：（I）使用链修饰的磷脂测定双层的水含量。（II）跨链修饰的磷脂的双层的离子运输。第2章：铜络合物脂质的合成，催化性能以及对电子的研究。
6. Plasma membrane expansion terminates in Saccharomyces cerevisiae secretion-defective mutants while phospholipid synthesis continues. [O] . R M Ramirez, T Ishida-Schick, B L Krilowicz, 1983

机译：质膜扩张终止于酿酒酵母分泌缺陷型突变体而磷脂合成仍在继续。
7. As (and when) you like it: on-demand phospholipid synthesis drives phagophore expansion during autophagy [O] . Shree Padma Metur, Daniel J. Klionsky 2020

机译：as（当时）您喜欢它：按需磷脂合成在自噬过程中推动吞噬膨胀

As (and when) you like it: on-demand phospholipid synthesis drives phagophore expansion during autophagy

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