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首页> 美国卫生研究院文献>British Journal of Clinical Pharmacology >Effects of Nigella sativa seeds (black cumin) on insulin secretion and lipid profile: A pilot study in healthy volunteers
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Effects of Nigella sativa seeds (black cumin) on insulin secretion and lipid profile: A pilot study in healthy volunteers

机译：Nigella sativa种子（黑孜然）对胰岛素分泌和脂质剖面的影响：健康志愿者的试验研究

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It has been claimed that Nigella sativa seeds (NSS), also known as black cumin, have antidiabetic and lipid‐lowering properties. Our pilot study investigated the effects of powdered NSS on insulin secretion and lipid profile in healthy male volunteers. We conducted a double‐blind, randomized, placebo‐controlled 4‐week trial in 30 subjects, receiving NSS powder (1 g/day) or placebo orally (15 subjects/group). Insulin secretion as determined by the hyperglycaemic clamp technique, insulin sensitivity as well as cholesterol and triglycerides serum concentrations, were measured before and after treatment. NSS powder administration was clinically well tolerated. It did not modify fasting glycaemia and insulinaemia, and was ineffective on glucose‐induced insulin secretion and insulin sensitivity. No significant changes on serum lipids were observed after treatment in any treatment groups, nor between the two treatment groups. However, in the treated group only, there was a significant correlation between total cholesterol change after treatment and its baseline level (r = −0.71, P = 0.006, n = 13), and between low‐density lipoprotein (LDL) cholesterol change after treatment and its baseline level (r = −0.74, P = 0.004, n = 13). No such correlations were found for high‐density lipoprotein (HDL) cholesterol, and for triglycerides. These results do not confirm any NSS effect on glucose regulation; however, they suggest that NSS powder may be of interest in lowering lipid concentrations in hyperlipidaemic subjects.
机译：已经声称果黑种草种子（NSS），也被称为黑色小茴香，具有抗糖尿病和降脂性质。我们的试点研究探讨粉状NSS对胰岛素分泌和血脂健康男性志愿者的影响。我们在30名受试者进行的双盲，随机，安慰剂对照的4个星期的试验，接收NSS粉末（1克/天）或安慰剂口服（15名受试者/组）。如由高血糖钳技术测定胰岛素分泌，胰岛素敏感性以及胆固醇和甘油三酯血清浓度，分别在处理之前和之后测量。 NSS粉给药的临床耐受性良好。它没有修改空腹血糖和血胰岛素，并且是对葡萄糖诱导的胰岛素分泌和胰岛素敏感性无效。治疗后观察到在任何治疗组对血脂没有显著的变化，也没有在两个治疗组之间。然而，该处理组中仅出现了一个显著总胆固醇变化之间处理后其基线水平和低密度脂蛋白（LDL）胆固醇变化之间后相关（r = -0.71，p = 0.006，N = 13），治疗和其基线水平相关（r = -0.74，p = 0.004，N = 13）。没有这样的相关性被发现的高密度脂蛋白（HDL）胆固醇和甘油三酯。这些结果不确认的葡萄糖调节任何NSS效果;然而，他们认为，NSS粉末可能是在高脂血症受试者降低血脂浓度的兴趣。

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