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首页> 美国卫生研究院文献>Clinical and Applied Thrombosis/Hemostasis >Relationship of Platelet Glycoprotein IIb/IIIa and CD62P WithHypercoagulable State After Oncologic Surgery
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Relationship of Platelet Glycoprotein IIb/IIIa and CD62P WithHypercoagulable State After Oncologic Surgery

机译：血小板糖蛋白IIB / IIIA和CD62P的关系肿瘤手术后高凝状态

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The biomarkers for predicting venous thromboembolic events (VTEs) after oncologicsurgery are still lacking. The current study aimed to analyze the relationshipsof CD62P and GP IIb/IIIa with hypercoagulation after oncologic surgery. A totalof 76 patients with primary abdominopelvic tumors in our hospital were enrolled.The patients were divided into groups A (malignancy with no VTE group), B(malignancy with VTE group), and C (benign with no VTE group). Twenty healthyvolunteers were selected as control. The plasma CD62P (4.69 ± 2.55 vs. 1.76 ±0.48) and the GP IIb/IIIa (9.28 ± 3.79 vs. 1.76 ± 0.48) levels in group A weresignificantly higher than those in the control group preoperatively. The CD62P(31.46 ± 17.13 vs. 13.51 ± 7.43, P < 0.05), GP IIb/IIIa(42.33 ± 21.82 vs. 13.51 ± 7.43, P < 0.05), and D-dimer(7.33 ± 2.34 vs. 2.03 ± 0.55, P < 0.05) levels in group Bwere markedly higher 7 days after operation compared with those in group A. TheCD62P and the GP IIb/IIIa exhibited a positive correlation with thehypercoagulable state after oncologic surgery.
机译：用于预测肿瘤后预测静脉血栓栓塞事件（VTE）的生物标志物手术仍然缺乏。目前的研究旨在分析关系CD62P和GP IIB / IIIA具有肿瘤手术后高凝。总计在我们院内患有76例患有初级腹部尿液肿瘤的患者。患者分为A组（没有VTE组的恶性肿瘤），B（与VTE组的恶性肿瘤）和C（无VTE组良性）。 20岁健康志愿者被选为控制。等离子体CD62P（4.69±2.55与1.76±0.48）和GP IIB / IIIa（9.28±3.79与1.76±0.48）A组显着高于对照组术前的那些。 CD62P.（31.46±17.13与13.51±7.43，P <0.05），GP IIB / IIIA（42.33±21.82 vs.13.51±7.43，P <0.05）和D-二聚体B组（7.33±2.34与2.03±0.55，P <0.05）水平与A组中的那些相比，术后7天显着更高。该CD62P和GP IIB / IIIa与呈阳性相关性肿瘤手术后高凝状态。

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