首页> 美国卫生研究院文献>Cold Spring Harbor Perspectives in Biology >Is It Possible to Develop Cancer Vaccines to Neoantigens What Are the Major Challenges and How Can These Be Overcome?: Neoantigens as Vaccine Targets for Cancer
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Is It Possible to Develop Cancer Vaccines to Neoantigens What Are the Major Challenges and How Can These Be Overcome?: Neoantigens as Vaccine Targets for Cancer

机译:是否有可能将癌症疫苗发展到新稻草原主要挑战是什么以及如何克服这些挑战?:Neoantigens作为癌症的疫苗目标

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摘要

Recent work by several groups has undoubtedly shown that we can produce cancer vaccines targeting neoantigens. However, each vaccine is essentially a single-use, patient-specific product, making this approach resource-intensive. For this reason, it is important to ask whether this approach will be any more successful than what has been attempted during the last 30 years using vaccines targeting self-epitopes. Here, we discuss what might be expected from neoantigen vaccines based on our experience in chronic viral infections, and how this new approach may be applied to cancer immunotherapy.
机译:毫无疑问,几个群体的最新工作毫无疑问地表明我们可以生产靶向新奥地利的癌症疫苗。然而,每种疫苗基本上是一种单用的患者特异性产品,使得这种方法是资源密集型的。出于这个原因,重要的是要询问这种方法是否会比使用靶向自表口的疫苗在过去30年中的尝试更成功。在这里,我们根据我们在慢性病毒感染的经验以及这种新方法可以应用于癌症免疫疗法的情况来讨论新稻草疫苗的预期。

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