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Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

机译：将resclvin d1和抗生素的共同递送到肺部肺部消化了炎症并清除小鼠的细菌

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摘要

Scheme (a) shows the generation of neutrophil membrane-derived nanovesicles (NVs) co-loaded with RvD1 and Ceftazidime (CAZ). b The nanovesicles home to the infectious lung to deliver both RvD1 and CAZ. RvD1 bind to GPCRs (ALX/FPR2), inhibiting the NF-κB pathway to decrease the expression of cell adhesion molecules, and mitigating neutrophil tissue infiltration and increasing the phagocytosis. Simultaneously, CAZ inhibits bacterial growth in the lung.

机译：方案（a）显示了与RVD1和CEFTALIDIME（CAZ）共同加载的中性粒细胞膜衍生的纳米寡核苷酸（NVS）的产生。 B纳米寡核桃回家给传染性肺部提供RVD1和CAZ。 RVD1与GPCR（ALX / FPR2）结合，抑制NF-κB途径以降低细胞粘附分子的表达，并减轻中性粒细胞组织浸润并增加吞噬作用。同时，CAZ抑制肺部细菌生长。

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期刊名称 Communications Biology
作者
Jin Gao; Sihan Wang; Xinyue Dong; Leon G. Leanse; Tianhong Dai; Zhenjia Wang;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 13
原文格式 PDF
正文语种
中图分类生物学;
关键词

机译：药物递送;纳米粒子;

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专利

1. Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation [J] . Abdulnour R. E., Sham H. P., Douda D. N., Mucosal immunology . 2016,第5期

机译：阿司匹林触发的resolvin D1在革兰氏阴性细菌性肺炎自我解决过程中产生，并调节宿主的免疫反应以解决肺部炎症
2. Protective Actions of Aspirin-Triggered (17R) Resolvin D1 and Its Analogue, 17R-Hydroxy-19-Para-Fluorophenoxy-Resolvin D1 Methyl Ester, in C5a-Dependent IgG Immune Complex–Induced Inflammation and Lung Injury [J] . Huifang Tang, Yanlan Liu, Chunguang Yan, The journal of immunology . 2014,第7期

机译：阿司匹林引发的（17R）Resolvin D1及其类似物17R-羟基-19-巴拉-氟苯氧基-Resolvin D1甲基酯在C5a依赖性IgG免疫复合物诱导的炎症和肺损伤中的保护作用。
3. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-Hydroxy-19-Para-Fluorophenoxy-Resolvin D1 Methyl Ester, in C5a-Dependent IgG immune complex-induced inflammation and lung injury [J] . TangH., LiuY., YanC., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2014,第7期

机译：阿司匹林触发的（17R）resolvin D1及其类似物17R-Hydroxy-19-Para-Fluorophenoxy-Resolvin D1甲基酯对C5a依赖性IgG免疫复合物诱导的炎症和肺损伤的保护作用
4. The Test and Evaluation of Resolvins E1 Pharmacodynamics in Mice with Acute Lung Injury [C] . Wenhong Qiu, Wenjian Song, Yeli Gong, International Conference on Measuring Technology and Mechatronics Automation . 2015

机译：Resolvins E1在急性肺损伤小鼠中的药效学测试和评估
5. Contribution of extracellular cyclophilin-CD147 interactions in lung inflammation [D] . Gwinn, William Michael 2006

机译：细胞外亲环蛋白-CD147相互作用在肺部炎症中的作用
6. Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation [O] . Raja Elie E. Abdulnour, Ho Pan Sham, David N. Douda, -1

机译：阿司匹林触发的resolvin D1在革兰氏阴性细菌性细菌性肺炎自我解决过程中产生并调节宿主的免疫反应以解决肺部炎症
7. Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation [O] . R E Abdulnour, H P Sham, D N Douda, 2015

机译：在自解决的革兰氏阴性细菌肺炎期间产生阿司匹林触发的reatvin D1，并调节肺炎的分辨率的宿主免疫应答

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

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