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首页> 美国卫生研究院文献>Experimental Biology and Medicine >Feature article: Silencing PSME3 induces colorectal cancerradiosensitivity by downregulating the expression of cyclin B1 andCKD1
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Feature article: Silencing PSME3 induces colorectal cancerradiosensitivity by downregulating the expression of cyclin B1 andCKD1

机译：特点文章：沉默PSME3诱导结直肠癌通过下调细胞周期蛋白B1的表达和辐射敏感性CKD1

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摘要

Resistance to radiotherapy remains a severe obstacle in the treatment ofhigh-risk colorectal cancer patients. Recent studies have indicated thatproteasome activator complex subunit 3 (PSME3) participates in the developmentand progression of various human malignancies and is proposed to play a role intumor radioresistance. However, the impact of PSME3 on radioresistance ofcolorectal cancer has been largely unknown. In the present study, the enhancedexpression of PSME3 was observed in colorectal cancer cells and tissue.Upregulation of PSME3 was significantly implicated in lymph node state,lymphovascular invasion, and Dukes' stage. Furthermore, high PSME3 expressionwas closely linked to poorer overall and progression-free survival in patientswith colorectal cancer. The study further demonstrated that the proliferative,invasive and migratory potential of colorectal cancer cells was effectivelyinhibited in vitro after silencing PSME3. Our results verifiedthat knockdown of PSME3 probably triggered cell cycle arrest at the G2/M phaseby downregulation of cyclinB1 and CDK1, thereby enhancing the radiosensitivityof colorectal cancer cells. These data illustrated that PSME3 is a promisingbiomarker predictive of colorectal cancer prognosis and silencing of PSME3 mayprovide with a new approach for sensitizing the radiotherapy in colorectalcancer.
机译：对放射疗法的抵抗仍然是治疗的严重障碍高风险结直肠癌患者。最近的研究表明蛋白酶体活化剂复合亚基3（PSME3）参与开发和各种人类恶性肿瘤的进展，并建议发挥作用肿瘤辐射敏感。但是，PSME3对辐射敏感度的影响结直肠癌在很大程度上是未知的。在本研究中，增强了在结肠直肠癌细胞和组织中观察PSME3的表达。PSME3的上调显着涉及淋巴结状态，淋巴敌入侵，和公爵的舞台。此外，高psme 3表达与患者的整体和无进展生存率密切相关用结肠直肠癌。该研究进一步证明增殖性，结直肠癌细胞的侵入性和迁移潜力有效沉默PSME3后体外抑制。我们的结果已核实PSME3的敲低可能在G2 / M阶段触发细胞周期骤停通过下调CyclinB1和CDK1，从而提高放射敏感性结直肠癌细胞。这些数据说明了PSME3是一个很有希望的生物标志物预测结直肠癌预后和PSME3的沉默提供一种致敏放射疗法的新方法癌症。

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