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Inclusion of IR-820 into Soybean-Phosphatides-Based Nanoparticles for Near-Infrared-Triggered Release and Endolysosomal Escape in HaCaT Keratinocytes at Insignificant Cytotoxic Level

机译：将IR-820用IR-820纳入大豆 - 磷酸酯的纳米粒子用于近红外触发的释放在哈达特毒素细胞的近红外触发释放和底糖体叶状物质在微不足道的细胞毒水平下

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The degradation of drugs within endolysosomes has been widely addressed as a cause of poor bioavailability. One of the strategies to allow molecules to escape from a destructive fate is to introduce a photosensitizing moiety into a drug carrier enabling the permeabilization of endosomes and endolysosomes upon irradiation. This paper presents an alternative delivery nanosystem composed of cost-effective soybean phosphatides mixed with IR-820, a near-infrared (NIR) sensitizer, to load various active compounds and trigger an endolysosomal escape with a low cytotoxic effect.

机译：鼻内瘤细胞中药物的降解已被广泛寻求生物利用度差的原因。允许分子从破坏性命运逃避的策略之一是将光敏部分引入药物载体中，使得在照射时能够渗透渗透物和底糖体。本文介绍了由与IR-820混合的经济高豆磷脂组成的替代交付纳米系统，近红外（NIR）敏化剂，以加载各种活性化合物，并以低细胞毒性效应触发内溶血剂逸出。

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期刊名称 International Journal of Nanomedicine
作者
Chaiyarerk Homsirikamol; Saroj Suvanasuthi; Kwanchanok Viravaidya-Pasuwat;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 21
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词

机译：IR-820;大豆磷酸酯;NIR-响应纳米颗粒;内溶血瘤逃逸;

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1. Investigation of Cytotoxicity Apoptotic and Inflammatory Responses of Biosynthesized Zinc Oxide Nanoparticles from Ocimum sanctum Linn in Human Skin Keratinocyte (Hacat) and Human Lung Epithelial (A549) Cells [J] . Bader Almutairi, Gadah Albahser, Rafa Almeer, Oxidative Medicine and Cellular Longevity . 2020,第47期

机译：对人体皮肤角膜细胞（HACAT）和人肺上皮（A549）细胞中生物合成氧化锌纳米粒子的细胞毒性凋亡和生物合成氧化锌纳米粒子的细胞毒性凋亡和炎症反应
2. Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells [J] . Ando Masanori, Horie Masanori, Akazawa-Ogawa Yoko, Bioscience, Biotechnology, and Biochemistry . 2016,第1期

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3. Intracellular localisation, geno- and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480). [J] . Naha PC, Bhattacharya K, Tenuta T, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2010,第2期

机译：聚N-异丙基丙烯酰胺（PNIPAM）纳米粒子对人角质形成细胞（HaCaT）和结肠细胞（SW 480）的细胞内定位，基因和细胞毒性反应。
4. Gold Nanoparticles with Immobilized β-cyclodextrin-capsaicin Inclusion Complex for Prolonged Capsaicin Release [C] . Y S Pestovsky, A Martinez-Antonio International Conference on Advanced Technologies in Manufacturing and Materials Engineering . 2018

机译：具有固定化的β-环糊精 - 辣椒素包合物的金纳米粒子，延长辣椒素释放
5. Luteinizing hormone-releasing hormone bound core-shell magnetite nanoparticles: Synthesis, characterization and studies of hyperthermia-induced cytotoxicity [D] . Mohammad, Faruq. 2011

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6. Investigation of Cytotoxicity Apoptotic and Inflammatory Responses of Biosynthesized Zinc Oxide Nanoparticles from Ocimum sanctum Linn in Human Skin Keratinocyte (Hacat) and Human Lung Epithelial (A549) Cells [O] . Bader Almutairi, Gadah Albahser, Rafa Almeer, 2020

机译：对人体皮肤角膜细胞（HACAT）和人肺上皮（A549）细胞中生物合成氧化锌纳米粒子的细胞毒性凋亡和生物合成氧化锌纳米粒子的细胞毒性凋亡和炎症反应
7. Investigation of Cytotoxicity Apoptotic and Inflammatory Responses of Biosynthesized Zinc Oxide Nanoparticles from Ocimum sanctum Linn in Human Skin Keratinocyte (Hacat) and Human Lung Epithelial (A549) Cells [O] . Bader Almutairi, Gadah Albahser, Rafa Almeer, 2020

机译：对人体皮肤角膜细胞（HACAT）和人肺上皮（A549）细胞中生物合成氧化锌纳米粒子的细胞毒性凋亡和生物合成氧化锌纳米粒子的细胞毒性凋亡和炎症反应

Inclusion of IR-820 into Soybean-Phosphatides-Based Nanoparticles for Near-Infrared-Triggered Release and Endolysosomal Escape in HaCaT Keratinocytes at Insignificant Cytotoxic Level

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