【2h】

Immunohistochemical analysis of pigment cell tumors in two cyprinid species

机译:两种脱盐物种中颜料细胞瘤的免疫组化分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Pigment cell tumors, also known as chromatophoromas, are cutaneous spindle cell neoplasms originating from pigment cells (chromatophores) in the dermis of teleosts, amphibians, and reptiles. Chromatophoromas share similar histologic morphology to other spindle cell tumors and are not always pigmented. Therefore, immunohistochemical analysis may be useful in distinguishing these neoplasms from tumors of other cellular origin when poorly pigmented. We performed 3 immunohistochemistry assays (PNL-2, melan A, and SOX10) on 8 cutaneous neoplasms from 8 teleosts diagnosed as chromatophoromas based on histologic morphology. Semiquantitative analysis of immunoreactivity was evaluated on each immunohistochemical assay using a 0–3 scale. PNL-2 exhibited mild-to-moderate (1 or 2) immunoreactivity in 7 of the cases, and resident chromatophores (internal control) were also immunoreactive in these cases. Melan A exhibited mild-to-moderate (1 or 2) immunoreactivity in 4 cases (and with resident chromatophores in these cases); SOX10 was not immunoreactive in any cases. Our results indicate that PNL-2 may be a useful marker in teleosts to distinguish tumors of chromatophore origin. Melan A could also be useful, but appears to be less sensitive, and SOX10 is likely not a useful marker for these neoplasms in teleosts.
机译:颜料细胞肿瘤,也称为染色体,是源自神经炎,两栖动物和爬行动物的真皮中的颜料细胞(染色体)的皮肤主轴细胞瘤。 Chromatophoromas与其他主轴细胞瘤共享相似的组织学形态,并不总是着色。因此,免疫组织化学分析可用于将这些肿瘤与其他细胞来源的肿瘤区分开,当着色不良时。我们在8个皮肤肿瘤上进行了3种免疫组织化学测定(PNL-2,Melan A和Sox10),从8个皮肤肿瘤诊断为基于组织学形态学​​诊断为染色体的阴离子。使用0-3等级对每个免疫组织化学测定评估免疫反应性的半定位分析。 PNL-2在其中7例中表现出温和至中等(1或2)免疫反应性,并且在这些情况下,驻留的染色体(内部对照)也免疫反应。 Melan A在4例中表现出轻度至中等(1或2)免疫反应性(在这些情况下与常驻染色体);在任何情况下,SOX10都没有免疫反应。我们的结果表明,PNL-2可以是电视剧中有用的标记,以区分染色体源的肿瘤。 Melan A也可能有用,但似乎敏感性较小,SOX10可能不是电视上这些肿瘤的有用标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号