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首页> 美国卫生研究院文献>Molecules >Development of Water-in-Oil Emulsions as Delivery Vehicles and Testing with a Natural Antimicrobial Extract
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Development of Water-in-Oil Emulsions as Delivery Vehicles and Testing with a Natural Antimicrobial Extract

机译：用自然抗菌提取物作为递送型载体的油包水乳液的发展

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Water-in-oil (W/O) emulsions have high potential for several industrial areas as delivery systems of hydrophilic compounds. In general, they are less studied than oil-in-water (O/W) systems, namely in what concerns the so-called fluid systems, partly due to problems of instability. In this context, this work aimed to produce stable W/O emulsions from a natural oil, sweet almond oil, to be further tested as vehicles of natural hydrophilic extracts, here exemplified with an aqueous cinnamon extract. Firstly, a base W/O emulsion using a high-water content (40/60, v/v) was developed by testing different mixtures of emulsifiers, namely Tween 80 combined with Span 80 or Span 85 at different contents. Among the tested systems, the one using a 54/46 (v/v) Span 80/Tween 80 mixture, and subjected to 12 high-pressure homogenizer (HPH) cycles, revealed to be stable up to 6 months, being chosen for the subsequent functionalization tests with cinnamon extract (1.25–5%; w/v; water-basis). The presence of cinnamon extract leaded to changes in the microstructure as well as in the stability. The antimicrobial and antioxidant analysis were evidenced, and a sustained behavior compatible with an extract distribution within the two phases, oil and water, in particular for the higher extract concentration, was observed.
机译：油状油（W / O）乳液对几个工业区具有高潜力作为亲水化合物的递送系统。通常，它们的研究较少，而不是水 - 水（O / W）系统，即所谓的流体系统，部分原因是由于不稳定性问题。在这种情况下，该工作旨在从天然油，甜杏仁油中产生稳定的W / O乳液，以进一步测试为天然亲水提取物的车辆，其目的是用肉桂提取物举例说明。首先，通过测试不同的乳化剂的不同混合物来开发使用高含水量（40/60，v / v）的碱基W / O乳液，即吐温80或在不同内容物的跨度80或跨度85组合。在测试的系统中，使用54/46（v / v）跨度80 /吐温80混合物，并进行12个高压均化器（HPH）循环，显示为稳定，最多6个月，被选择为随后用肉桂提取物进行官能化试验（1.25-5％; w / v;水基）。肉桂提取物的存在引入了微观结构以及稳定性的变化。观察到抗微生物和抗氧化剂分析，观察到与两相，油和水中的提取物分布相容的持续行为，特别是对于更高的提取物浓度。

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