首页> 美国卫生研究院文献>Neuro-Oncology >EXTH-28. TARGETED POLYGIONS ENGINEERED WITH SURFACE miRNAs FOR COMBINED MULTIMODALITY IMAGING AND ENHANCEMENT OF TEMOZOLOMIDE TREATMENT: A NOVEL INTRANASALLY-DELIVERED THERANOSTIC STRATEGY AGAINST GLIOBLASTOMA

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EXTH-28. TARGETED POLYGIONS ENGINEERED WITH SURFACE miRNAs FOR COMBINED MULTIMODALITY IMAGING AND ENHANCEMENT OF TEMOZOLOMIDE TREATMENT: A NOVEL INTRANASALLY-DELIVERED THERANOSTIC STRATEGY AGAINST GLIOBLASTOMA

机译：exth-28。有针对性的聚合物用于表面miRNA用于组合多模成像和增强替莫唑胺治疗：一种鼻内递送治疗胶质母细胞瘤的新药

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We investigate intranasal targeted delivery of theranostic Polyfunctional Gold Iron Oxide Nanoparticles (PolyGIONs) surface loaded with therapeutic microRNAs to allow sensitizing of GBM cells to systemic temozolomide (TMZ), as well as multimodality molecular, anatomic and microscopic imaging.

机译：我们研究了负载治疗MicroRNA的鼻内靶向递送治疗细胞的鼻内靶向递送，以允许GBM细胞敏化到全身蜕皮素（TMZ），以及多层分子，解剖学和微观成像。

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期刊名称 Neuro-Oncology
作者
Uday Sukumar; Rayhaneh Afjei; Tarik Massoud; Ramasamy Paulmurugan;
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年(卷),期 2019(21),Suppl 6
年度 2019
页码 vi87–vi88
总页数 2
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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专利

1. Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide [J] . Uday K. Sukumar, Rajendran J.C. Bose, Meenakshi Malhotra, Biomaterials . 2019,第期

机译：胎儿递送靶向多官能金 - 氧化铁纳米粒子，其加载治疗微大稻草，用于组合治疗微瘤成像和锭剂的胶质母细胞瘤
2. Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer [J] . Zhiwei Li, Shengnan Yin, Liang Cheng, Advanced Functional Materials . 2014,第16期

机译：基于多峰成像的磁靶向增强治疗方法对癌症的选择性消融
3. MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma [J] . Costa Pedro M., Cardoso Ana L., Custodia Carlos, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2015,第Null期

机译：靶向肿瘤的纳米颗粒与舒尼替尼联合介导的miRNA-21沉默：胶质母细胞瘤的新型多模式基因治疗方法
4. H_2O_2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy using Molecularly Engineered Theranostic Nanoparticles [C] . Dongwon Lee, Eunkyeong Jung, Changsun Rang, Society for Biomaterials annual meeting and exposition . 2018

机译：H_2O_2可激活的对比度增强光声成像和抗血栓治疗的分子工程化治疗纳米颗粒。
5. Improving delivery of elacridar to enhance efficacy of molecularly-targeted agents in treatment of glioblastoma. [D] . Sane, Ramola Vishwas. 2012

机译：改善elacridar的递送以增强分子靶向药物治疗胶质母细胞瘤的功效。
6. Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity [O] . Lei Wang, Xusha Zhou, Weixuan Zou, 2020

机译：含有靶向HER2合成的miRNA的外泌体并工程化以粘附在肿瘤细胞表面上的HER2上表现出增强的抗肿瘤活性
7. Pre-clinical investigation of the effect of combining the cytotoxic agent Temozolomide with a dual mTORC2 inhibitor for the treatment of glioblastoma and establishment of an imageable surgical resection model of glioblastoma [O] . Sweeney Kieron J 2014

机译：临床前研究将细胞毒性剂替莫唑胺与mTORC2双重抑制剂联合治疗胶质母细胞瘤的效果并建立可成像的胶质母细胞瘤手术切除模型

EXTH-28. TARGETED POLYGIONS ENGINEERED WITH SURFACE miRNAs FOR COMBINED MULTIMODALITY IMAGING AND ENHANCEMENT OF TEMOZOLOMIDE TREATMENT: A NOVEL INTRANASALLY-DELIVERED THERANOSTIC STRATEGY AGAINST GLIOBLASTOMA

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