• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Neuro-Oncology >MNGI-14. PROGNOSTIC FEATURES OF MALIGNANT MENINGIOMA: EVALUATION OF AGGRESSIVE MENINGIOMAS WITHIN A LARGE RURAL HOSPITAL SYSTEM DATABASE AND FIRST REPORT OF A METASTATIC CHORDOID MENINGIOMA TO THE LUNG
【2h】

MNGI-14. PROGNOSTIC FEATURES OF MALIGNANT MENINGIOMA: EVALUATION OF AGGRESSIVE MENINGIOMAS WITHIN A LARGE RURAL HOSPITAL SYSTEM DATABASE AND FIRST REPORT OF A METASTATIC CHORDOID MENINGIOMA TO THE LUNG

机译：mngi-14。恶性脑膜瘤的预后特征：大型农村医院系统数据库中侵略性脑膜瘤的评价及转移症状脑膜瘤到肺部的第一报告

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Meningiomas comprise 37% of primary brain tumors, arise extra-axially from the arachnoid cap cells, and are typically identified by classic imaging and histopathologic features. Blacks, females, and people age 65+ have higher incidence rate - partially correlated with hormonal states, high body mass index, and known genetic predispositions. Prognostication is otherwise based on histopathologic findings and 90% of meningiomas are classified as benign (WHO grade I). Despite use of these prognostic tools, clinicians often observe a more divergent post-operative clinical course. While several pre-clinical studies have identified putative oncogenic influencers, many have failed to show correlation in human trials. Here, we evaluate a single institutional meningioma database stratified by geodemographic and clinical data to identify novel integrated prognostic indicators for aggressive tumor natural history. Our database contains 3,528 image-confirmed meningiomas between 1992–2019. This report focused on 415 pathology-confirmed cases between 2006–2019: WHO grades I, II, III were 73% (n=303), 25% (n=103), and 2% (n=9) respectively, 71% female predominance (n=294), median age at diagnosis 57-years-old, and 97.5% were white race. Thus far, full exome sequencing has been completed on >50% of cases and >80% have available tumor tissue for future testing as part of this rural Pennsylvania database with high incident aggressive and/or multiply recurrent meningiomas. We selected four representative cases to compare post-operative prognostication to observed clinical outcomes and provide molecular/genetic, histopathologic, treatment modality, comorbid, and other clinical features associated with morbidity/mortality. Included in this patient review is the first reported case of a rare (< 1%) chordoid meningioma, multiply recurrent despite 8-years of aggressive treatment modalities, including surgery, radiation, chemotherapy and androgen-blockade, with eventual extracranial metastasis to the lung, a meningiocarcinoma, if you will. Thorough interrogation of the completed database could yield novel predictive indicators of clinically aggressive meningiomas and guide clinical decision-making for optimized surveillance in high-risk patients.
机译：脑膜瘤包括原发性脑肿瘤的37％，从蛛网膜帽细胞产生额外的轴向，并且通常由经典成像和组织病理学特征鉴定。黑人，女性，人们65岁以上有较高的发病率 - 与荷尔蒙的状态，高体重指数，和已知的遗传倾向部分相关。预测否则根据病理结果和脑膜瘤的90％被归类为良性（WHO I级）。尽管使用这些预后工具，医生经常看到一个更加发散术后临床过程。虽然几个临床前研究已鉴定出的推定致癌影响力，很多都未能表现出人体试验的相关性。在这里，我们评估的地理人口统计和临床数据分层的单一体制脑膜瘤的数据库，以确定攻击性的肿瘤自然史新型集成的预后指标。我们的数据库有2092至19年之间的3528图像证实脑膜瘤。此报告集中在415病理学确诊病例2006年至2019年之间：WHO等级I，II，III分别为73％（N = 303），25％（N = 103），和2％（N = 9）分别为71％女性占多数（N = 294），平均年龄在57诊断岁，97.5％是白人。到目前为止，全基因组测序已经完成> 50％的病例和> 80％的可用肿瘤组织未来的测试，因为这农村宾夕法尼亚数据库与高发生积极的和/或乘脑膜瘤复发的一部分。我们选择了四个代表性的案例到术后预后比较观察到的临床结果和提供分子/遗传，病理组织学，治疗模式，共病，和与发病率/死亡率相关联的其它临床特征。包括在此患者审查是一种罕见的（<1％）脊索样脑膜瘤的首次报道，尽管8年积极的治疗方式，包括手术，放疗，化疗和雄激素阻断的乘法反复发作，与最终颅外转移到肺，一个meningiocarcinoma，如果你愿意。已完成的数据库可能会产生临床攻击脑膜瘤的新的预测指标和指导的深入审讯临床决策的高危患者的优化监控。

著录项

相似文献

  • 外文文献
  • 中文文献
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号