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TMOD-33. AN INTEGRATED APPROACH COMBINING MATHEMATICAL AND GENOMIC METHODS TO REVEAL THE OPTIMAL TIMING OF THERAPEUTIC INTERVENTION IN WHO GRADE II DIFFUSE GLIOMA

机译：tmod-33。一种综合方法组合数学和基因组方法揭示世卫组成级弥漫性胶质瘤治疗干预的最佳时间

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In WHO grade II diffuse gliomas (low-grade gliomas, hereafter called LGGs), chemotherapy and radiotherapy contribute to prolonged survival but could induce somatic mutations. The optimal timing of treatment in LGGs remain poorly understood. To delineate this, we designed a mathematical model for tumor growth and investigate the association among the treatment, malignant transformation (MT), and the accumulation of somatic mutations revealed by whole exome sequencing (WES) in LGGs.

机译：在世卫组织II级弥漫性胶质瘤（低级Gliomas，下文称为LGG），化疗和放射疗法有助于长时间存活，但可以诱导体细胞突变。 LGGS中治疗的最佳时间仍然很清楚。为了描绘这一点，我们设计了一种用于肿瘤生长的数学模型，并研究治疗，恶性转化（MT）之间的关联，以及在LGGS中全体外壳测序（WES）揭示的体细胞突变的积累。

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期刊名称 Neuro-Oncology
作者
Kosuke Aoki; Takashi Yamamoto; Hiromichi Suzuki; Sachi Maeda; Melissa Ranjit; Kazuya Motomura; Hideo Nakamura; Yoshitaka Narita; Mitsutoshi Nakada; Shoichi Deguchi; Masahiro Mizoguchi; Yasutomo Momii; Yoshihiro Muragaki; Tatsuya Abe; Jiro Akimoto; Toshihiko Wakabayashi; Hiroshi Haeno; Atsushi Natsume;
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年(卷),期 2019(21),Suppl 6
年度 2019
页码 vi270
总页数 1
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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1. Current therapeutic approaches to diffuse grade II and III gliomas [J] . Alberto Picca, Giulia Berzero, Marc Sanson Therapeutic advances in neurological disorders. . 2018,第11期

机译：弥散性II级和III级神经胶质瘤的当前治疗方法
2. Current therapeutic approaches to diffuse grade II and III gliomas [J] . Picca Alberto, Berzero Giulia, Sanson Marc Therapeutic advances in neurological disorders. . 2018,第Jana期

机译：目前的弥漫性II和III级胶质瘤的治疗方法
3. Molecular genetics of low-grade gliomas: Genomic alterations guiding diagnosis and therapeutic intervention. 11th annual frye-halloran brain tumor symposium meeting report [J] . JonesP.S., DunnG.P., BarkerIIF.G., Neurosurgical focus . 2013,第2期

机译：低度神经胶质瘤的分子遗传学：基因组改变指导诊断和治疗干预。第十一届年度弗雷-霍尔兰脑瘤研讨会会议报告
4. Efficacy of Radiomics and Genomics in Predicting TP53 Mutations in Diffuse Lower Grade Glioma [C] . Zeina A. Shboul, Khan M. Iftekharuddin Conference on Medical Imaging : Biomedical Applications in Molecular, Structural, and Functional Imaging . 2020

机译：辐射瘤和基因组学在弥漫性较低级胶质瘤中TP53突变预测的疗效
5. Interventions for Integrated Mathematics A Study on the Relationship of Mathematics Interventions for Ninth Grade Integrated Mathematics Students at a Suburban Chicago High School [D] . Green, Kerri. 2018

机译：集成数学的干预芝加哥郊区高中九年级集成数学学生的数学干预关系研究
6. Current therapeutic approaches to diffuse grade II and III gliomas [O] . Alberto Picca, Giulia Berzero, Marc Sanson 2018

机译：弥散性II级和III级神经胶质瘤的当前治疗方法
7. Therapeutic Options and the Timing of Radiation Therapy for Low-grade Glioma(Treatment of Diffuse Astrocytoma Grade 2) [O] . Minoru Tanaka, Tomoki Todo 2009

机译：低级胶质瘤的治疗选择和放射治疗的时间（<特别问题>弥漫性星形细胞瘤2级）

TMOD-33. AN INTEGRATED APPROACH COMBINING MATHEMATICAL AND GENOMIC METHODS TO REVEAL THE OPTIMAL TIMING OF THERAPEUTIC INTERVENTION IN WHO GRADE II DIFFUSE GLIOMA

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