“Biologic therapies” encompass techniques such as the injection of platelet-rich plasma(PRP) and the collection and injection of progenitor “stem” cells derived from bonemarrow, amnion, or fat tissue. The underlying rationale for use of these techniques isthe potential to improve symptoms and to possibly augment healing of tissues that haverelatively poor intrinsic healing ability such as cartilage, tendon, ligament, bone,muscle, and meniscus. Although basic science data suggest strong potential for theseapproaches to improve tissue healing, there are currently only limited clinical data tosupport use of these techniques for treatment of musculoskeletal conditions. A largenumber of unproven therapies are being marketed directly to athletes, withunsubstantiated claims of efficacy and lack of information about risks, productmanufacturing, and realistic expectations of outcomes.2,14,15
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