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首页> 美国卫生研究院文献>Therapeutic Advances in Musculoskeletal Disease >Oral disease-modifying antirheumatic drugs and immunosuppressants with antiviral potential including SARS-CoV-2 infection: a review
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Oral disease-modifying antirheumatic drugs and immunosuppressants with antiviral potential including SARS-CoV-2 infection: a review

机译：口腔疾病 - 改性抗病毒潜力的抗抗抗体药物和免疫抑制剂包括SARS-COV-2感染：综述

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摘要

There have been several episodes of viral infection evolving into epidemics in recent decades, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest example. Its high infectivity and moderate mortality have resulted in an urgent need to find an effective treatment modality. Although the category of immunosuppressive drugs usually poses a risk of infection due to interference of the immune system, some of them have been found to exert antiviral properties and are already used in daily practice. Recently, hydroxychloroquine and baricitinib have been proposed as potential drugs for SARS-CoV-2. In fact, there are other immunosuppressants known with antiviral activities, including cyclosporine A, hydroxyurea, minocycline, mycophenolic acid, mycophenolate mofetil, leflunomide, tofacitinib, and thalidomide. The inherent antiviral activity could be a treatment choice for patients with coexisting rheumatological disorders and infections. Clinical evidence, their possible mode of actions and spectrum of antiviral activities are included in this review article.
机译：近几十年，已经有几次病毒感染的病毒感染剧集，严重的急性呼吸综合征冠状病毒2（SARS-COV-2）是最新的例子。它的高感染性和中度死亡率导致了迫切需要找到有效的治疗方式。虽然免疫抑制药物的类别通常由于免疫系统的干扰而导致感染的风险，但其中一些已被发现施用抗病毒性质并且已经在日常实践中使用。最近，已经提出了羟基氯喹和甘特inia作为SARS-COV-2的潜在药物。实际上，还有其他免疫抑制剂，包括抗病毒活性，包括环孢菌素A，羟基脲，米诺环素，霉酚酸，霉酚酸酯，乳酰胺，豆孢菌和沙利度胺。固有的抗病毒活性可能是共存风湿病学疾病和感染患者的治疗选择。临床证据，他们可能的行动模式和抗病毒活动的范围包括在本综述文章中。

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