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首页> 美国卫生研究院文献>Trends in Hearing >Impact of Aging and the Electrode-to-Neural Interface on Temporal Processing Ability in Cochlear-Implant Users: Amplitude-Modulation Detection Thresholds
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Impact of Aging and the Electrode-to-Neural Interface on Temporal Processing Ability in Cochlear-Implant Users: Amplitude-Modulation Detection Thresholds

机译：老化的影响和电极对神经界面对耳蜗植入用户的时间处理能力：幅度调制检测阈值

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Although cochlear implants (CIs) are a viable treatment option for severe hearing loss in adults of any age, older adults may be at a disadvantage compared with younger adults. CIs deliver signals that contain limited spectral information, requiring CI users to attend to the temporal information within the signal to recognize speech. Older adults are susceptible to acquiring auditory temporal processing deficits, presenting a potential age-related limitation for recognizing speech signals delivered by CIs. The goal of this study was to measure auditory temporal processing ability via amplitude-modulation (AM) detection as a function of age in CI users. The contribution of the electrode-to-neural interface, in addition to age, was estimated using electrically evoked compound action potential (ECAP) amplitude growth functions. Within each participant, two electrodes were selected: one with the steepest ECAP slope and one with the shallowest ECAP slope, in order to represent electrodes with varied estimates of the electrode-to-neural interface. Single-electrode AM detection thresholds were measured using direct stimulation at these two electrode locations. Results revealed that AM detection ability significantly declined as a function of chronological age. ECAP slope did not significantly impact AM detection, but ECAP slope decreased (became shallower) with increasing age, suggesting that factors influencing the electrode-to-neural interface change with age. Results demonstrated a significant negative impact of chronological age on auditory temporal processing. The locus of the age-related limitation (peripheral vs. central origin), however, is difficult to evaluate because the peripheral influence (ECAPs) was correlated with the central factor (age).
机译：虽然人工耳蜗植入（独联体）是在任何年龄的成年重度听力损失的可行的治疗选择，老年人可能会处于不利的地位与年轻的成年人相比。 CI的递送包含有限的光谱信息信号，需要CI用户参加到所述时间信息的信号内，以识别语音。老年人易患获得听觉时间处理缺陷，提出一个潜在的与年龄相关的限制识别独联体传递语音信号。本研究的目的是测量通过振幅调制（AM）检测听觉时间处理能力作为年龄在CI用户的功能。所述电极 - 神经接口的贡献，除了年龄，使用电诱发复合动作电位（ECAP）振幅增长函数估计。内每个参与者，选择两个电极：一个与最陡的斜率ECAP和一个与所述浅坡ECAP中，为了表示与电极 - 神经接口的变化估计电极。单电极AM检测阈值利用直接刺激在这两个电极的位置进行测定。结果显示显著下跌的实足年龄的一个函数，AM探测能力。 ECAP斜率没有显著影响AM检波，但ECAP斜率下降（变浅）随着年龄的增加，这表明影响因素随着年龄的电极 - 神经接口变化。结果显示实足年龄的听觉时间处理一个显著的负面影响。与年龄有关的限制的轨迹（外周与中枢），但是，很难评价，因为外围影响（ECAPs）与核心因素（年龄）相关。

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