首页> 美国卫生研究院文献>Journal for Immunotherapy of Cancer >M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer
【2h】

M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer

机译:M1Hot肿瘤相关的巨噬细胞促进组织植物记忆T细胞浸润和生存在人肺癌中

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and phenotypes by integration of signals in the tumor microenvironment. Depending on how macrophages are activated, they may adopt so-called M1-like, antitumor or M2-like, protumor profiles. In many solid tumors, a dominance of M2-like macrophages is associated with poor outcomes but in some tumor types, strong M1-like profiles are linked to better outcomes. We aimed to investigate the interrelationship of these TAM populations to establish how they modulate the efficacy of the adaptive immune system in early lung cancer.
机译:肿瘤相关巨噬细胞(TAMS)在确定适应性免疫系统和肿瘤抗免疫划分的抗肿瘤效应之间的结果是有争议的。巨噬细胞通过肿瘤微环境中的信号进行调节它们的活性和表型。根据巨噬细胞的激活方式,它们可以采用所谓的M1,抗肿瘤或M2样的探测器型材。在许多实体瘤中,M2样巨噬细胞的优势与结果不良,但在一些肿瘤类型中,强大的M1样曲线与更好的结果有关。我们旨在调查这些TAM种群的相互关系,以确定它们如何调节自适应免疫系统在早期肺癌中的疗效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号