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首页> 美国卫生研究院文献>The Journal of Pharmacy Technology : jPT : Official Publication of the Association of Pharmacy Technicians >The Physical Compatibility of Clinically Used Concentrations of Diltiazem Hydrochloride With Heparin Sodium
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The Physical Compatibility of Clinically Used Concentrations of Diltiazem Hydrochloride With Heparin Sodium

机译：盐酸肝钠临床用浓度的临床浓度的物理兼容性

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Background: Acute treatment of atrial fibrillation often requires concomitant intravenous (IV) continuous infusions of unfractionated heparin and diltiazem. Concomitantly infusing these medications through the same IV line minimizes multiple IV sites. Diltiazem and heparin visual compatibility have been previously investigated but with limited drug dwell times and differing drug concentrations leading to inconsistent published results. Objective: To investigate the physical compatibility of diltiazem hydrochloride at concentrations of 5 and 1 mg/mL combined with an equal volume of heparin sodium 100 units/mL. Methods: Using a 0.22-µm filter, 15 mL of heparin sodium were placed into a polyvinyl chloride infusion bag followed by 15 mL of either diltiazem hydrochloride 5 or 1 mg/mL. Admixtures were prepared in triplicate. Each admixture was investigated for visual precipitation, spectrophotometric absorbance, and pH change at baseline and 1, 5, 8, and 24 hours after mixing. Physical incompatibility was determined by visual observation, increased spectrophotometric absorbance, and demonstrative pH changes. Results: Each diltiazem 5 mg/mL admixture exhibited a slight haze and enhanced absorbance readings indicating turbidity while none revealed a demonstrative pH change. None of the diltiazem 1 mg/mL assessments revealed visual precipitation or suggested turbidity. Only one pH reading at 5 hours revealed a demonstrative change from baseline. Conclusions: Our findings indicate that infusing diltiazem hydrochloride 5 mg/mL with heparin sodium 100 units/mL in the same IV line cannot be advocated. In contrast, our findings suggest that heparin sodium 100 units/mL infused with diltiazem hydrochloride 1 mg/mL is physically compatible but chemical stability was not assessed.
机译：背景：心房颤动的急性治疗通常需要伴随的静脉注射（IV）连续输注未分割的肝素和Diltizem。同时通过相同的IV线输注这些药物，最小化多个IV位点。先前已经研究了Diltiazem和肝素视觉相容性，但药物停留时间有限，不同的药物浓度导致不一致的公布结果。目的：探讨盐酸盐浓度为5-1mg / ml的浓度的浓度与等体积的肝素钠100单位/ ml。方法：使用0.22-μm过滤器，将15ml肝素钠置于聚氯乙烯输注袋中，然后盐酸盐5ml盐酸盐5或1mg / ml。癌症一式三份制备。调查每种混合物进行视觉沉淀，分光光度吸光度和基线和1,5,8和24小时的pH变化。通过视觉观察，分光光度吸光度增加和证明性pH变化来确定物理不相容性。结果：每个Diltiazem 5 mg / ml混合物表现出轻微的雾度和增强的吸光度读数，表明浊度，而没有显示出证明性pH变化。 Diltiazem 1 mg / ml评估中没有一个显示出视觉降水或建议的浊度。 5小时只有一个pH读数透露了基线的证据变化。结论：我们的研究结果表明，在同一IV线中，用肝素盐酸钠盐酸盐将5mg / ml注入到同一IV线中。相比之下，我们的研究结果表明，肝素100单位/ ml注入盐酸尔尼堤ZEM1mg / ml物理相容但未评估化学稳定性。

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