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首页> 美国卫生研究院文献>BMC Infectious Diseases >Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases Brandenburg Germany – a case report
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Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases Brandenburg Germany – a case report

机译：对德国勃兰登堡邦勃兰登堡德国以前已知的致命人体诞生病毒1脑炎的调查 - 案例报告

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Phylogeny and geography of BoDV-1 from endemic areas. A Phylogenetic analysis of BoDV-1 sequences. Representative partial human and animal BoDV-1 sequences (1824 nucleotides, representing genome positions 54 to 1877 of BoDV-1 reference genome {"type":"entrez-nucleotide","attrs":{"text":"U04608","term_id":"439575","term_text":"U04608"}}U04608) from the endemic regions in Germany (GER), Austria (AUT), Switzerland (SUI) and Liechtenstein (LIE) were analysed by Neighbor-Joining algorithm and Jukes-Cantor distance model in Geneious Prime. The tree was rooted using sequence BoDV-2 No/98 ({"type":"entrez-nucleotide","attrs":{"text":"AJ311524","term_id":"15718106","term_text":"AJ311524"}}AJ311524, not shown). The sequence generated in this study is depicted in black and bold. Previously published sequences from alpacas and horses from the federal state of Brandenburg (BB) are depicted in grey. Values at branches represent support in 1000 bootstrap replicates. Only bootstrap values ≥70 at major branches are shown. Cluster designations, host and geographic origin are indicated according to previously published work [1–3, 7, 9–13]. B The human case reported in this study is presented together with previously published BoDV-1 infections of alpacas and horses in Brandenburg and sequence-confirmed BoDV-1 infections of shrews (triangles), domestic mammals (circles) and humans (squares) with available geographic localization in known endemic regions [1–3, 7, 9–13]. Colors represent regional BoDV-1 sequence clusters (see Figure 1A). Human cases are generally marked at the centre of their county of residence. Imprecise geographic information and/or aberrant infection sources due to travel cannot be excluded for humans and domestic mammals. The area within the dashed blue line represents the presumed endemic area of BoDV-1. Grey letters represent federal states in Germany (BB: Brandenburg; BW: Baden-Wuerttemberg; BY: Bavaria; HE: Hesse; NI: Lower Saxony; SN: Saxony; ST: Saxony-Anha TH: Thuringia) and Austria (UA: Upper Austria; VA: Vorarlberg) and cantons in Switzerland (GR: Grisons; SG: St. Gall) for which confirmed BoDV-1 infections are presented
机译：系统发育和来自疫区BoDV-1地理学。 BoDV-1序列的系统进化分析。代表性的部分人类和动物BoDV-1序列（1824个核苷酸，代表基因组位置54至BoDV-1参考基因组{ “类型” 的1877： “的Entrez核苷酸”， “ATTRS”：{ “文本”： “U04608”，” term_id “：” 439575" ， “term_text”： “从德国（GER），奥地利（AUT），瑞士（SUI）和列支敦士登（LIE）的流行地区U04608”}} U04608）由邻接法算法分析朱克斯 - 康托距离模型Geneious总理。 “的Entrez核苷酸”， “ATTRS”：：树，使用序列BoDV-2无/ 98（{ “类型” 植根{ “文本”： “AJ311524”， “term_id”： “15718106”， “term_text”：” AJ311524" }} AJ311524，未示出）。在这项研究中所产生的顺序以黑色和大胆的描述。先前公开的从勃兰登堡（BB）的联邦国家羊驼和马序列以灰色示出。在分行数值代表1000个引导重复支持。只有在主要分支引导值≥70所示。簇指定，主机和地理来源是根据先前公开的工作[1-3，7，9-13]表示。 B中的人的情况下，本研究报告所用勃兰登堡可用羊驼和马先前公布BoDV-1感染和序列证实BoDV-1的鼩（三角形）感染，家养哺乳动物（圆圈）和人（正方形）一起呈现在已知的流行地区的地理定位[1-3，7，9-13]。颜色代表的区域BoDV-1序列的簇（参见图1A）。人的案件一般都标在其居住的县的中心。不精确的地理信息和/或异常的传染源因出差不能排除对人类和家养哺乳动物。的蓝色虚线内的区域表示BoDV-1的假定流行区。灰色字母代表的联邦州在德国（BB：勃兰登堡; BW：巴登 - 符腾堡州，BY：巴伐利亚; HE：黑森州; NI：下萨克森州; SN：萨克森; ST：萨克森 - 安哈尔特州; TH：图林根州）和奥地利（UA：上奥地利; VA：福拉尔贝格州）和各州在瑞士（GR：格劳宾登州; SG：圣加仑）为证实BoDV-1感染都

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