• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Poultry Science >Effects of selenide chitosan sulfate on glutathione system in hepatocytes and specific pathogen-free chickens
【2h】

Effects of selenide chitosan sulfate on glutathione system in hepatocytes and specific pathogen-free chickens

机译：硒化壳聚糖硫酸盐对肝细胞和特异性无病原体鸡谷胱甘肽系统的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study aimed to investigate the effects of selenide chitosan sulfate (Se-CTS-S) on glutathione (GSH) system in hepatocytes and chickens. Chitosan, sodium selenite (Na2SeO3), selenide chitosan, chitosan sulfate (CTS-S), and Se-CTS-S were added to the culture medium and the basal diets; glutathione peroxidase (GSH-Px) activity, GSH content, total antioxidant capacity (T-AOC), and mRNA levels of cellular GPx (GPx-1) and phospholipid hydroperoxide GPx (GPx-4) in vivo and in vitro were determined. The results showed that Se-CTS-S increased (P < 0.05) GPx-1 and GPx-4 mRNA levels in hepatocytes and livers, and GSH-Px activity, GSH content, and T-AOC in the medium, hepatocytes, plasma, and livers compared with the control and chitosan treatments. Compared with CTS-S, Se-CTS-S treatments increased (P < 0.05) GPx-1 and GPx-4 mRNA levels in hepatocytes and livers, and GSH-Px activity, GSH content, and T-AOC capacity in the medium, hepatocytes, and livers. Compared with Na2SeO3 and CTS-Se, Se-CTS-S increased (P < 0.05) GPx-1 mRNA levels in hepatocytes and livers, GPx-4 mRNA levels in hepatocytes and livers, GSH-Px activity in the medium, hepatocytes, and livers, GSH contents in plasma and livers, and T-AOC in the medium, plasma, and livers. Thus, Se-CTS-S showed better biological activity that mainly benefited from the synergistic effects of Se and sulfate on GSH system.
机译：本研究旨在探讨硒丁烷硫酸盐（SE-CTS-S）对肝细胞和鸡谷胱甘肽（GSH）体系的影响。壳聚糖，硒（Na2SeO3），硒化酰壳聚糖，壳聚糖硫酸盐（CTS-S）和SE-CTS-S加入到培养基和基础饮食中;确定谷胱甘肽过氧化物酶（GSH-PX）活性，GSH含量，总抗氧化容量（T-AOC）和体内细胞GPX（GPX-1）和磷脂氢过氧化物GPX（GPX-4）的mRNA水平。结果表明，SE-CTS-S在肝细胞和肝细胞和肝脏的GPX-1和GPX-4 mRNA水平增加（P <0.05），GSH-PX活性，GSH含量和T-AOC，肝细胞，血浆，等离子体，和肝脏与控制和壳聚糖治疗相比。与CTS-S，SE-CTS-S治疗相比（P <0.05）GPX-1和GPX-4 mRNA水平肝细胞和肝脏，GSH-PX活性，GSH含量和培养基中的T-AOC容量增加，肝细胞和肝脏。与Na2SeO3和CTS-SE相比，SE-CTS-S增加（P <0.05）肝细胞和肝脏中的GPX-1 mRNA水平，肝细胞和肝细胞的GPX-4 mRNA水平，中等，肝细胞中的GSH-PX活性和血浆和肝脏中的GSH内容，以及中等，血浆和肝脏的T-AOC。因此，SE-CTS-S显示出更好的生物活性，主要受益于SE和硫酸盐对GSH系统的协同作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号