首页> 美国卫生研究院文献>Advanced Science >Smart Drug Delivery: Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor (Adv. Sci. 10/2021)

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Smart Drug Delivery: Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor (Adv. Sci. 10/2021)

机译：智能药物递送：肿瘤外泌体由低pH重编程是有效的靶向载体用于智能药物递送和对同源肿瘤的个性化治疗（ADV。10/2021）

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In article number 2002787, Yugang Wang, Wei Wei, Guanghui Ma, and co‐workers develop an exosome‐based platform for smart drug delivery and personalized antitumor therapy. They discover that the exosomes released from low‐pH treated tumor cells have the strong uptake efficiency and targeting ability for their parent cells. Such “magical” characteristics are based on a glycerolipid selfaggregation‐enhanced uptake mechanism. These reprogrammed exosomes are further utilized as smart carriers for dual‐loading of photosensitizer and chemodrug, which are capable of specifically accumulating in tumor tissue, selectively releasing chemodrug in response to the near‐infrared irradiance and achieving safe and potent antitumor effects.

机译：在2002787年，尤扬王，魏伟，广汇马，兼同事开发了基于外科的智能药物递送和个性化抗肿瘤治疗平台。他们发现从低pH处理的肿瘤细胞释放的外泌体具有雄性细胞的强烈吸收效率和靶向能力。这种“魔法”特征基于甘油脂溢性增强的摄取机制。这些重编程的外来体进一步用作光敏剂和化学细胞的双负载的智能载体，其能够在肿瘤组织中特异性积聚，以响应近红外辐照度和实现安全和有效的抗肿瘤效应而在肿瘤组织中选择性地释放化学rug。

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期刊名称 Advanced Science
作者
Changguo Gong; Xiao Zhang; Min Shi; Feng Li; Shuang Wang; Yan Wang; Yugang Wang; Wei Wei; Guanghui Ma;
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年(卷),期 2021(8),10
年度 2021
页码 2170052
总页数 1
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专利

1. Chaperonin-GroEL as a Smart Hydrophobic Drug Delivery and Tumor Targeting Molecular Machine for Tumor Therapy [J] . Yi Yuan, Chong Du, Cuiji Sun, Nano letters . 2018,第2期

机译：作为肿瘤疗法的综合疏水性药物输送和肿瘤靶向分子机
2. A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy [J] . Li Zhen, Fan Jialong, Tong Chunyi, Nanomedicine . 2019,第15期

机译：基于羧化石墨烯量子点的肿瘤靶向化疗的智能药物递送纳米系统
3. Drug Delivery in Plants: Targeted Drug Delivery in Plants: Enzyme‐Responsive Lignin Nanocarriers for the Curative Treatment of the Worldwide Grapevine Trunk Disease Esca (Adv. Sci. 15/2019) [J] . Jochen Fischer, Sebastian J. Beckers, Doungporn Yiamsawas, Advanced Science . 2019,第15期

机译：植物中的药物递送：植物中的靶向药物递送：酶反应性木质素纳米载体用于全球葡萄树干疾病ESCA的治疗治疗（ADV。SCI。15/2019）
4. A Novel Macrophage-Based Microrobot Bearing Multiple Smart Nanotherapeutics for Targeting and Drug Delivery to Solid Tumors* This research was supported by the Bio Medical Technology Development Program of the National Research Foundation (NRF) funded b [C] . Van Du Nguyen, Viet Ha Le, Chang-Sei Kim, IEEE International Conference on Biomedical Robotics and Biomechatronics . 2018

机译：一种新型的基于巨噬细胞的微型机器人，该机器人具有多种用于靶向和向实体瘤药物递送的智能纳米疗法*。该研究得到了美国国家研究基金会（NRF）资助的生物与医学技术开发计划的资助b
5. Fibrinogen-coated lipid-based drug delivery systems: A novel approach for targeted delivery of anti-cancer taxanes to tumors. [D] . Jakate, Abhijeet S. 2003

机译：纤维蛋白原包衣的脂质基药物递送系统：一种将抗癌紫杉烷类药物靶向递送至肿瘤的新方法。
6. Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor [O] . Changguo Gong, Xiao Zhang, Min Shi, 2021

机译：低pH重新编程的肿瘤外泌体是智能药物递送和对其同源肿瘤的个性化治疗的有效靶向载体
7. Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor [O] . Changguo Gong, Xiao Zhang, Min Shi, 2021

机译：低pH重新编程的肿瘤外泌体是智能药物递送和对其同源肿瘤的个性化治疗的有效靶向载体
8. Formulated Delivery of Enzyme/Pro-Drug and Cytokine Gene Therapy to Promote Immune Reduction of Treated and Remote Tumors in Mouse Models of Prostate Cancer [R] . Russell, P. 2005

机译：配方提供酶/前药和细胞因子基因治疗促进小鼠前列腺癌模型中治疗和远程肿瘤的免疫减少

Smart Drug Delivery: Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor (Adv. Sci. 10/2021)

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