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首页> 美国卫生研究院文献>Poultry Science >In-ovo Newcastle disease virus vaccine strain TS09-C protects commercial chickens against Newcastle disease in the presence of maternally derived antibodies
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In-ovo Newcastle disease virus vaccine strain TS09-C protects commercial chickens against Newcastle disease in the presence of maternally derived antibodies

机译：在ovo新城疫病毒疫苗菌株TS09-C在出现母体衍生抗体存在下保护商业鸡免受新城疫的影响

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摘要

Maternally derived antibodies (MDA) substantially interfere with active immunity in post-hatch vaccination, although they provide early protection against disease through passive immunity in young chickens. Previously, Newcastle disease virus (NDV) strain TS09-C was demonstrated to be safe and immunogenic as in-ovo vaccine in specific-pathogen-free chickens. Here, we evaluated the safety, protective efficacy, and duration of clinical protection of the TS09-C virus as an in-ovo vaccine for commercial chickens in the presence of Maternally derived antibodies against NDV. This vaccine was safe in commercial chickens and provided at least 80% protection against a virulent NDV challenge for 3 mo, despite inducing a low hemagglutinin-inhibition titer. For commercial chickens, the protective efficacy of the in-ovo vaccination was markedly higher than that of posthatch vaccination, and the cellular immune response might play an important role in the higher protective efficacy of the in-ovo vaccine. The overall results indicate that the maternally derived antibodies against NDV do not significantly interfere with the ability of the in-ovo vaccine strain TS09-C to induce protective cellular immunity.
机译：母体衍生的抗体（MDA）基本上干扰孵化后疫苗接种的积极免疫，但它们通过年轻鸡的被动免疫提供了早期的疾病保护。以前，纽卡斯尔疾病病毒（NDV）菌株TS09-C被证明是安全和免疫原性，如在无特异性的无病原鸡中的卵卵疫苗。在这里，我们评估了TS09-C病毒的安全性，保护性疗效和临床保护的持续时间，作为用于对NDV的母体衍生抗体存在的商业鸡的卵型疫苗。这种疫苗在商业鸡中是安全的，并且尽管诱导低血凝素抑制滴度，但为3Mo提供了至少80％的毒性NDV挑战。对于商业鸡，卵巢疫苗接种的保护效果明显高于Posthatch疫苗接种，并且细胞免疫反应可能在卵巢疫苗的较高保护效果中发挥重要作用。总体结果表明，对NDV的母体衍生的抗体不会显着干扰卵巢疫苗菌株TS09-C诱导保护性细胞免疫的能力。

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