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Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2‐M checkpoint modulation

机译：升高的Tab182通过G2-M检查点调制增强食管鳞状细胞癌的辐射敏感度

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摘要

Radiotherapy is one of the main strategies for the treatment of esophageal squamous cell carcinoma (ESCC). However, treatment failure often occurs due to the emergence of radioresistance. In this study, we report a key regulator of radiation sensitivity, termed TAB182 that may become an ideal biomarker and therapeutic target to overcome radioresistance.

机译：放射疗法是治疗食管鳞状细胞癌（ESCC）的主要策略之一。然而，由于放射群的出现，经常发生治疗失败。在这项研究中，我们报告了一种辐射敏感性的关键调节器，其称为替代克服放射率的理想生物标志物和治疗靶标。

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期刊名称 Cancer Medicine
作者
Yuandong Cao; Aidi Gao; Xiaoqing Li; Han Min; Chao He; Xinchen Sun; Wei‐Qun Ding; Jundong Zhou;
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作者单位

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年(卷),期 2021(10),9
年度 2021
页码 3101–3112
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

机译：食管鳞状细胞癌;FHL2;G2-M细胞周期检查点;辐射避险率;TAB182;

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专利

1. A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2‐mediated epigenetic modulation in esophageal squamous cell carcinoma [J] . Zhenchuan Liu, Kaiqing Wu, Shaorui Gu, Clinical and Translational Medicine . 2021,第9期

机译：甲基转移酶样14 / miR-99A-5P / Tribble 2阳性反馈电路通过组蛋白脱乙酰酶2介导的食管鳞状细胞癌中介导的表观遗传调节促进癌症干细胞持久性和辐射敏感度
2. Mn-superoxide dismutase overexpression enhances G2 accumulation and radioresistance in human oral squamous carcinoma cells. [J] . Kalen AL, Sarsour EH, Venkataraman S, Antioxidants and redox signalling . 2006,第7a8期

机译：锰超氧化物歧化酶的过表达增强人口腔鳞状细胞癌细胞中的G2积累和抗辐射性。
3. Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G₂ checkpoint and suppression of homologous recombination repair [J] . Qin Qin, Hongyan Cheng, Jing Lu, Journal of Hematology and Oncology . 2014,第1期

机译：小分子存活蛋白抑制剂YM155通过取消G _{2 检查点和抑制同源重组修复来增强食道鳞状细胞癌的放射增敏作用}
4. PLK1 Promotes Invasion of Esophageal Squamous Cell Carcinoma Cells through Inducing Epithelial-mesenchymal Transition [C] . Jiyu Ju, Wenjing Yu, Chunling Zhao International Conference on Applied Sciences, Engineering and Technology . 2014

机译：PLK1通过诱导上皮 - 间充质转换来促进食管鳞状细胞癌细胞的侵袭
5. Identification of Novel Candidate Tumor Suppressor Genes at 11q and 15q for Esophageal Squamous Cell Carcinoma and Nasopharyngeal Carcinoma via Integrative Cancer Epigenetics and Genomics. [D] . Li, Jisheng. 2010

机译：通过综合癌症表观遗传学和基因组学鉴定食管鳞状细胞癌和鼻咽癌的11q和15q新型候选肿瘤抑制基因。
6. Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair [O] . Qin Qin, Hongyan Cheng, Jing Lu, 2014

机译：小分子存活蛋白抑制剂YM155通过取消G2检查点和抑制同源重组修复来增强食道鳞状细胞癌的放射增敏作用
7. Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair [O] . Qin Qin, Hongyan Cheng, Jing Lu, 2014

机译：小分子存活蛋白抑制剂YM155通过取消G2检查点和抑制同源重组修复来增强食道鳞状细胞癌的放射增敏作用

Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2‐M checkpoint modulation

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