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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Fecundability and Sterility by Age: Estimates Using Time to Pregnancy Data of Japanese Couples Trying to Conceive Their First Child with and without Fertility Treatment
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Fecundability and Sterility by Age: Estimates Using Time to Pregnancy Data of Japanese Couples Trying to Conceive Their First Child with and without Fertility Treatment

机译：令人兴奋的性和无菌按年龄：估计使用日本夫妇的怀孕数据试图设想他们的第一个孩子没有生育治疗

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Fecundability, the probability of conception in a month or in a menstrual cycle, varies across and within age groups for both women and men. Fertility treatment has become common in a number of countries including Japan, but its impact on the age pattern of fecundability is unknown. By utilizing the previously collected data on time to pregnancy (TTP) of Japanese couples trying to conceive their first child, the present study aimed to estimate fecundability and sterility by women’s age and to assess how the estimates may differ by including or excluding assisted conceptions. Duration between discontinuing contraception and conception (including both natural and assisted) resulted in a live birth was called TTP-all, and the duration ending with natural conception was called TTP-natural. TTP-natural was censored when a participant received fertility consultation or treatment. A zero-inflated beta distribution model was used to estimate a proportion of sterile (zero probability of conception) and a distribution of fecundability for each age group. Parameters of the distribution were estimated using the maximum likelihood method. When TTP-all and TTP-natural were used, the sterile proportion of the whole sample was, respectively, 2% and 14%, and the median (interquartile range) of fecundability was, respectively, 0.10 (0.04, 0.19) and 0.11 (0.05, 0.19). The median (interquartile range) of fecundability was 0.18 (0.10, 0.29) for women aged 24 years or younger and 0.05 (0.02, 0.13) for 35–39 years old when TTP-all was used, and the estimates were quite similar with those based on TTP-natural: it was 0.18 (0.10, 0.29) for women aged 24 years or younger and 0.06 (0.00, 0.15) for 35–39 years old. Exclusion of assisted conceptions resulted in larger proportions of sterility, but it had little impact on median or interquartile ranges of fecundability estimates. Fecundability is overall lower at higher ages, while interquartile ranges are overlapping, suggesting that inter-individual variability of fecundability within an age group is as large as the variability across age groups.
机译：生育能力，在一个月或在月经周期受孕的几率，跨变化和年龄组的女性和男性中。生育治疗已成为许多国家，包括日本的普通，但其对生育能力的年龄格局的影响是未知的。通过利用在时间之前收集的数据来的日本夫妇尝试怀孕的第一个孩子，本研究旨在评估妇女的年龄生育力和不育，并评估如何估计可以由包括或不包括辅助概念不同妊娠（TTP）。停止避孕和受孕（包括自然和辅助）之间的时间导致活产被称为TTP-所有，并与自然受孕结束时间被称为TTP-自然。 TTP-自然当参与者接受生育咨询或治疗审查。一个零膨胀β分布模型来估计无菌的比例（概念的零概率）和生育能力的每个年龄组的分布。分布的参数是使用最大似然法估计。当TTP-所有和TTP-自然被使用，整个样品的无菌比例，分别为2％和14％，并且平均（四分位数间距）受孕的是，分别为0.10（0.04，0.19）和0.11（ 0.05，0.19）。生育能力的中位数（IQR）为24岁以下和0.05岁女性0.18（0.10，0.29）（0.02，0.13）为35-39岁的时候，TTP-全部使用，并估计是与那些颇为相似基于TTP-自然：它为0.18（0.10，0.29），24岁以下和0.06（0.00，0.15）对于35-39岁女性，年龄。辅助观念的排斥导致了更大的不育的比例，但对生育能力估计的中位数或四分范围的影响很小。生育能力被整体降低在较高的年龄，而四分位数间距是重叠的，这表明一个年龄组内的生育能力的个体间变异性是一样大的各年龄组的可变性。

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