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首页> 美国卫生研究院文献>Neurobiology of Stress >Is neuroticism really bad for you? Dynamics in personality and limbic reactivity prior to during and following real-life combat stress
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Is neuroticism really bad for you? Dynamics in personality and limbic reactivity prior to during and following real-life combat stress

机译：神经质是对你真的不好吗？在现实战斗压力期间和之后和之后的人格和肢体反应性的动态

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The personality trait of neuroticism is considered a risk factor for stress vulnerability, putatively via its association with elevated limbic reactivity. Nevertheless, majority of evidence to date that relates neuroticism, neural reactivity and stress vulnerability stems from cross-sectional studies conducted in a “stress-free” environment. Here, using a unique prospective longitudinal design, we assessed personality, stress-related symptoms and neural reactivity at three time points over the course of four and a half years; accounting for prior to, during, and long-time following a stressful military service that included active combat. Results revealed that despite exposure to multiple potentiality traumatic events, majority of soldiers exhibited none-to-mild levels of posttraumatic and depressive symptoms during and following their military service. In contrast, a quadratic pattern of change in personality emerged overtime, with neuroticism being the only personality trait to increase during stressful military service and subsequently decrease following discharge. Elevated neuroticism during military service was associated with reduced amygdala and hippocampus activation in response to stress-related content, and this association was also reversed following discharge. A similar pattern was found between neuroticism and hippocampus-anterior cingulate cortex (ACC) functional connectivity in response to stress-related content. Taken together these findings suggest that stressful military service at young adulthood may yield a temporary increase in neuroticism mediated by a temporary decrease in limbic reactivity, with both effects being reversed long-time following discharge. Considering that participants exhibited low levels of stress-related symptoms throughout the study period, these dynamic patterns may depict behavioral and neural mechanisms that facilitate stress resilience.
机译：神经质的人格特征被认为是压力脆弱性的危险因素，通过其与肢体反应性升高的关联借鉴。尽管如此，迄今为止，迄今为止，神经质症，神经反应性和胁迫脆弱性患有在“无胁迫”环境中进行的横截面研究的截图。在这里，使用独特的前瞻性纵向设计，我们在四年半的时间内评估了个性，压力相关的症状和神经反应性;在包括积极战斗的紧张的军事服务后，期间和长期核算。结果表明，尽管暴露于多种潜力创伤事件，但大多数士兵在其军事服务期间和遵循其军事服务期间的抑郁症和抑郁症状的无程度轻度水平。相比之下，人格的二次变化模式出现了加时，神经质是在压力军事服务期间唯一增加的个性特质，随后在出院后减少。在军事管理期间的神经统计学升高与asygdala和海马激活的减少有关，响应于应激相关的含量，并且在出院后，这种关联也逆转。神经质和海马 - 前型刺痛皮质（ACC）在响应于应力相关含量的函数连通性之间发现了类似的模式。占据这些研究结果表明，年轻成年的压力军事服务可能会产生临时减少肢体反应性介导的神经质症的临时增加，两种效应都在出院后长期逆转。考虑到参与者在整个研究期间表现出低水平的压力相关症状，这些动态模式可以描绘促进应力弹性的行为和神经机制。

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