首页> 美国卫生研究院文献>Neuro-Oncology >EMBR-17. DE-INTENSIFICATION OF RADIOTHERAPY IN RIGOROUSLY DEFINED LOW-RISK WNT-SUBGROUP MEDULLOBLASTOMA IS ASSOCIATED WITH UNACCEPTABLY HIGH RISK OF NEURAXIAL FAILURE: RESULTS FROM THE PROSPECTIVE FOR-WNT STUDY

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EMBR-17. DE-INTENSIFICATION OF RADIOTHERAPY IN RIGOROUSLY DEFINED LOW-RISK WNT-SUBGROUP MEDULLOBLASTOMA IS ASSOCIATED WITH UNACCEPTABLY HIGH RISK OF NEURAXIAL FAILURE: RESULTS FROM THE PROSPECTIVE FOR-WNT STUDY

机译：搭配-17。在严格定义的低风险Wnt-subgromoup medulloblastoma的放射治疗的解除愈合与无可受欢迎的神经衰竭风险有关：来自WNT研究的前瞻性研究结果

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Medulloblastoma is a heterogenous disease comprising four molecular subgroups (WNT, SHH, Group 3, and Group 4) with varying outcomes. Excellent long-term survival (>90%) has prompted de-intensification of therapy in WNT-subgroup medulloblastoma globally. FOR-WNT is one such prospective study (CTRI/2017/12/010767) testing the hypothesis that focal conformal radiotherapy (RT) (54Gy/30 fractions/6-weeks) with avoidance of upfront craniospinal irradiation (CSI) followed by standard adjuvant chemotherapy significantly reduces RT-related late toxicity without unduly compromising survival in low-risk WNT-subgroup medulloblastoma (residual tumor <1.5cm2 with no evidence of metastases in children aged between 3–16 years).

机译：Medulloblastoma是包含四种分子亚组（Wnt，Shh，第3组和第4组）的异源性疾病，其结果不同。优异的长期生存（> 90％）促进在全球WNT-亚组髓质母细胞瘤的治疗进行解除。对于WNT是一种这样的前瞻性研究（CTRI / 2017/12 / 010767）测试局灶性保形放疗（RT）（54GY / 30分数/ 6周），避免前期颅辐射（CSI），然后是标准佐剂的假设化学疗法显着降低了RT相关的晚期毒性，不会过度损害低风险的WNT-亚组Medulloblastoma（残留肿瘤<1.5cm2，没有3-16岁的儿童转移的证据）。

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期刊名称 Neuro-Oncology
作者
Tejpal Gupta; Shizan Pervez; Archya Dasgupta; Abhishek Chatterjee; Rahul Krishnatry; Jayant GodaSastri; Maya Prasad; Girish Chinnaswamy; Sridhar Epari; Ayushi Sahay; Neelam Shirsat; Prakash Shetty; Aliasgar Moiyadi; Farnaz Shaikh; Nazia Bano; Rakesh Jalali;
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年(卷),期 2021(23),Suppl 1
年度 2021
页码 i9
总页数 1
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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1. Is there a patient population with squamous cell carcinoma of the head and neck region who might benefit from de-intensification of postoperative radiotherapy? A monocentric retrospective analysis of a previously defined low-risk patient population treated with standard-of-care radiotherapy [J] . Onbasi Yonca, Lettmaier Sebastian, Hecht Markus, Strahlentherapie und Onkologie . 2019,第6期

机译：是否有患者患有头部和颈部区域的鳞状细胞癌，他们可能会受益于术后放疗的解除愈合？用护理标准放射治疗治疗先前定义的低风险患者人群的单眼回顾分析
2. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. [J] . Gajjar A, Chintagumpala M, Ashley D, The lancet oncology . 2006,第10期

机译：在新诊断的髓母细胞瘤（St Jude Medulloblastoma-96）患儿中，进行风险适应性颅脑放射治疗，然后大剂量化疗和干细胞抢救：一项前瞻性，多中心试验的长期结果。
3. A double-blinded, prospective study to define antigenemia and quantitative real-time polymerase chain reaction cutoffs to start preemptive therapy in low-risk, seropositive, renal transplanted recipients. [J] . Elias David-Neto, Ana H K Triboni, Flavio J Paula, Transplantation: Official Journal of the Transplantation Society . 2014,第10期

机译：一项双盲前瞻性研究，旨在确定抗原血症和定量实时聚合酶链反应临界值，以开始在低风险，血清反应阳性，肾移植受者中进行抢先治疗。
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EMBR-17. DE-INTENSIFICATION OF RADIOTHERAPY IN RIGOROUSLY DEFINED LOW-RISK WNT-SUBGROUP MEDULLOBLASTOMA IS ASSOCIATED WITH UNACCEPTABLY HIGH RISK OF NEURAXIAL FAILURE: RESULTS FROM THE PROSPECTIVE FOR-WNT STUDY

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