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首页> 美国卫生研究院文献>Nutrients >Effects of n-3 Polyunsaturated Fatty Acid Supplementation in the Prevention and Treatment of Depressive Disorders—A Systematic Review and Meta-Analysis
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Effects of n-3 Polyunsaturated Fatty Acid Supplementation in the Prevention and Treatment of Depressive Disorders—A Systematic Review and Meta-Analysis

机译：N-3多不饱和脂肪酸补充在抑郁症预防和治疗中的影响 - 一种系统综述及荟萃分析

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N-3 polyunsaturated fatty acids (PUFAs) have been suggested to affect depressive disorders. This review aims to determine the effect of n-3 PUFAs on depressive symptoms in people with or without diagnosed depression. Medline, PsycINFO, and Cochrane CENTRAL databases were searched for randomized controlled trials (RCTs) assessing the association between n-3 PUFAs and depressive symptoms or disorders as outcomes. A random-effects meta-analysis of standardized mean difference (SMD) with 95% confidence intervals (CI) was performed. Twenty-five studies (7682 participants) were included. Our meta-analysis (20 studies) indicated that n-3 PUFA supplementation lowered depressive symptomology as compared with placebo: SMD = −0.34, 95% CI: −0.55, −0.12, I2 = 86%, n = 5836, but a possible publication bias cannot be ruled out. Subgroup analyses indicated no statistically significant difference by treatment duration of <12 vs. ≥12 weeks, presence of comorbidity, or severity of depressive symptoms. Nevertheless, beneficial effects were seen in the subgroups of studies with longer treatment duration and with no depression and mild to moderate depression. Subgroup analysis by eicosapentaenoic acid (EPA) dosage revealed differences in favor of the lower EPA dosage. Sensitivity analysis including studies with low risk of bias seems to confirm the overall result. Supplementation of n-3 PUFA appears to have a modest beneficial effect on depressive symptomology, although the quality of evidence is still insufficient.
机译：N-3多不饱和脂肪酸（PUFA）已被建议来影响抑郁症。这次审查的目的是确定与n-3多不饱和脂肪酸对人有或没有诊断出抑郁症抑郁症状的效果。 MEDLINE，PsycINFO和Cochrane CENTRAL数据库进行搜索的随机对照试验（随机对照试验）评估的n-3多不饱和脂肪酸和抑郁症状或障碍，结果之间的关联。进行标准化平均差异的随机效应的荟萃分析（SMD）与95％置信区间（CI）。 25项研究（7682人参加）都包括在内。我们的荟萃分析（20项研究）表明的n-3 PUFA补充降低抑郁症状与安慰剂相比：SMD = -0.34，95％CI：-0.55，-0.12，I2 = 86％，N = 5836，但在可能的发表偏倚不能排除。亚组分析表明由<12与≥12周的治疗持续时间，共病的存在，或抑郁症状的严重程度没有统计学差异显著。然而，有益效应可见在较长的治疗时间，并没有抑郁症和轻度至中度抑郁症研究小组。由二十碳五烯酸（EPA）的剂量亚组分析显示有利于低EPA剂量的差异。敏感性分析，包括带有偏见的低风险的研究似乎印证了整体效果。 N-3 PUFA的补充似乎对抑郁症状温和有益效果，但证据的质量仍然不足。

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