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首页> 美国卫生研究院文献>Journal of the Endocrine Society >Thyroid Function in 3000 Cases of Patients With Atrial Fibrillation Treated With Catheter Ablation
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Thyroid Function in 3000 Cases of Patients With Atrial Fibrillation Treated With Catheter Ablation

机译：3000例含有导管消融治疗的心房颤动患者3000例甲状腺功能

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Objective: Thyroid hormones have various effects on cardiac and circulatory systems, leading to arrhythmias and heart failure. In Europe and the United States, it has been reported that elevated thyroid hormones within the normal range have been reported to be associated with a risk of atrial fibrillation, however, there was no report on Japanese cases, a country that differs in iodine intake and ethnicity from the West. Therefore, we evaluated the abnormality of thyroid function in a large number of cases of atrial fibrillation (AF) who received catheter ablation (RFCA) in Japan. Methods: We evaluated 2,937 cases of atrial fibrillation (2,084 males, mean age 64.1±10.7 years and 853 females, 69.0±8.5 years) who underwent RFCA at the Gunma Prefectural Cardiovascular Center between 2012 and 2018. As a control we used a total of 15,660 participants for health check-up (9,176 males, mean age 49.7±9.8 years and 6,484 females, 48.9±10.3 years) from 2006 to 2013, and we evaluated thyroid function after adjusting for gender-specific age. Results: The prevalence of overt hyperthyroidism was significantly higher in the RFCA-treated male group (0.43%) than in the control group (0.07%), even after adjusting for age (p<0.01). Similarly, the prevalence of subclinical hyperthyroidism was also significantly higher in the RFCA-treated male group (3.12%) than in the control group (0.94%) after adjusting for age (p<0.01). On the other hand, subclinical hypothyroidism was significantly lower in the RFCA-treated group after adjusting for age (2.97% in the RFCA-treated group and 3.93% in the control group, p<0.01). Females showed the same results as males. Conclusions: In an iodine rich country Japan, not only overt hyperthyroidism but also subclinical hyperthyroidism is an obvious risk factor for severe atrial fibrillation in Japan. Intriguingly, subclinical hypothyroidism might contribute to the prevention of atrial fibrillation, suggesting that slightly higher serum TSH levels might be better for elderlies.
机译：目的：甲状腺激素对心脏和循环系统具有各种影响，导致心律失常和心力衰竭。据报道，在欧洲和美国，据报道，正常范围内的甲状腺激素升高有与心房颤动的风险有关，然而，没有关于日语案件的报告，这是一种不同于碘摄入的国家来自西方的种族。因此，我们评估了在日本接受导管消融（RFCA）的大量心房颤动（AF）的大量心房颤动病例中的甲状腺功能异常。方法：我们评估2937箱子房颤（2084名男性，平均年龄64.1±10.7年，女性853，69.0±8.5岁）谁2012年和2018年之间进行了射频消融在群马县心血管中心作为对照，我们一共使用15,660名参与者的健康检查（9,176名男性，平均49.7±9.8岁，6,484名女性，48.9±10.3岁）从2006年到2013年，我们评估了调整性别特定年龄后的甲状腺功能。结果：RFCA治疗的雄性组（0.43％）在对照组（0.07％）中，脱脂甲状腺功能亢进的患病率显着高于对照组（0.07％），即使在调节年龄后（P <0.01）。同样，在调整年龄调整后的RFCA处理的雄性组（3.12％）中，亚临床甲状腺功能亢进症的患病率也显着高（3.12％）（0.94％）（P <0.01）。另一方面，在调整年龄（RFCA治疗组中2.97％的2.97％和对照组中的3.93％，P <0.01）后，亚临床甲状腺功能减退症在RFCA治疗组中显着降低。女性显示与雄性相同的结果。结论：在富含富含碘的国家，不仅脱脂甲状腺功能亢进，而且亚临床甲状腺功能亢进是日本严重心房颤动的明显危险因素。有趣的是，亚临床甲状腺功能减退症可能有助于预防心房颤动，表明血清TSH水平略高，对老年人来说可能更好。

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