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首页> 美国卫生研究院文献>Sensors (Basel Switzerland) >Polyvinyl Chloride Modified Carbon Paste Electrodes for Sensitive Determination of Levofloxacin Drug in Serum Urine and Pharmaceutical Formulations
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Polyvinyl Chloride Modified Carbon Paste Electrodes for Sensitive Determination of Levofloxacin Drug in Serum Urine and Pharmaceutical Formulations

机译：聚氯乙烯改性碳糊电极用于血清尿液和药物制剂中左氧氟沙星药物的敏感测定

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Levofloxacin (LF) is a medically important antibiotic drug that is used to treat a variety of bacterial infections. In this study, three highly sensitive and selective carbon paste electrodes (CPEs) were fabricated for potentiometric determination of the LF drug: (i) CPEs filled with carbon paste (referred to as CPE); (ii) CPE coated (drop-casted) with ion-selective PVC membrane (referred to as C-CPE); (iii) CPE filled with carbon paste modified with a plasticizer (PVC/cyclohexanone) (referenced as P-CPE). The CPE was formulated from graphite (Gr, 44.0%) and reduced graphene oxide (rGO, 3.0%) as the carbon source, tricresyl phosphate (TCP, 47.0%) as the plasticizer; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl] borate (St-TFPMB, 1.0%) as the ion exchanger; and levofloxacinium-tetraphenylborate (LF-TPB, 5.0%) as the lipophilic ion pair. It showed a sub-Nernstian slope of 49.3 mV decade−1 within the LF concentration range 1.0 × 10−2 M to 1.0 × 10−5 M, with a detection limit of 1.0 × 10−5 M. The PVC coated electrode (C-CPE) showed improved sensitivity (in terms of slope, equal to 50.2 mV decade−1) compared to CPEs. After the incorporation of PVC paste on the modified CPE (P-CPE), the sensitivity increased at 53.5 mV decade−1, indicating such improvement. The selectivity coefficient (log KLF2+,Fe+3pot.) against different interfering species (Na+, K+, NH4+, Ca2+, Al3+, Fe3+, Glycine, Glucose, Maltose, Lactose) were significantly improved by one to three orders of magnitudes in the case of C-CPE and P-CPE, compared to CPEs. The modification with the PVC membrane coating significantly improved the response time and solubility of the LF-TPB within the electrode matrix and increased the lifetime. The constructed sensors were successfully applied for LF determination in pharmaceutical preparation (Levoxin® 500 mg), spiked urine, and serum samples with high accuracy and precision.
机译：左氧氟沙星（LF）是一种医学上重要的抗生素药物，用于治疗各种细菌感染。在该研究中，制造了三种高度敏感和选择性的碳浆料电极（CPE），用于电位测定LF药物的测定：（i）填充有碳浆料的CPE（称为CPE）; （ii）用离子选择性PVC膜（称为C-CPE）涂覆（滴液）的CPE; （iii）用增塑剂（PVC /环己酮）改性碳浆料的CPE（称为P-CPE）。将CPE从石墨（GR，44.0％）和将石墨烯（RGO，3.0％）的石墨源，三氯联基（TCP，47.0％）作为增塑剂的石墨氧化物（Rg。四硫酸钠[3,5-双（三氟甲基）苯基]硼酸酯（ST-TFPMB，1.0％）作为离子交换剂;和左氧嘧啶 - 四苯基硼酸盐（LF-TPB，5.0％）作为亲脂离子对。它在LF浓度范围内为1.0×10-2米至1.0×10-5米的49.3mV十四型-1的子宫颈斜率，检测限为1.0×10-5 m .PVC涂层电极（C -CPE）与CPE相比，显结了改善的灵敏度（在斜坡方面，等于50.2mV十年 - 1）。在改性CPE（P-CPE）上掺入PVC浆料后，灵敏度在53.5 mV十年内-1增加，表明这种改进。针对不同干扰物质（Na +，K +，NH 4 +，Ca 2+，Al3 +，Fe 3，Ca 2+，Al3 +，Fe 3 +，甘氨酸，葡萄糖，麦芽糖，乳糖）的选择性系数（Log Klf2 +，Fe + 3Pot）在情况下显着提高1至三个大小的次数与C-C-CPE和P-CPE相比，与CPE相比。具有PVC膜涂层的改性显着改善了LF-TPB在电极基质内的响应时间和溶解度并增加了寿命。成功地应用于具有高精度和精度的药物制剂（Levoxin®500mg），尖刺尿液和血清样品中的LF测定。

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